Understanding how we age: insights into inflammaging

Longevity & Healthspan

Helen C Roberts¹  Harnish P Patel¹  David B Bartlett²  Daniel Baylis¹ 

[1] Academic Geriatric Medicine, University of Southampton, Southampton, UK;MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK

关键词: Older people;    Inflammation;    Inflammaging;    Frailty;    DHEAS;    Cortisol;    Ageing;   

Others  :  803853
DOI  :  10.1186/2046-2395-2-8

 received in 2012-11-27, accepted in 2013-04-05,  发布年份 2013

【 摘 要 】

Inflammaging is characterized by the upregulation of the inflammatory response that occurs with advancing age; its roots are strongly embedded in evolutionary theory.

Inflammaging is believed to be a consequence of a remodelling of the innate and acquired immune system, resulting in chronic inflammatory cytokine production.

Complex interrelated genetic, environmental and age-related factors determine an individual’s vulnerability or resilience to inflammaging. These factors include polymorphisms to the promoter regions of cytokines, cytokine receptors and antagonists, age-related decreases in autophagy and increased adiposity. Anti-inflammaging describes the upregulation of the hypothalamic-pituitary axis in response to inflammaging, leading to higher levels of cortisol, which in turn may be detrimental, contributing to less successful ageing and frailty. This may be countered by the adrenal steroid dehydroepiandrosterone, which itself declines with age, leaving certain individuals more vulnerable. Inflammaging and anti-inflammaging have both been linked with a number of age-related outcomes, including chronic morbidity, functional decline and mortality. This important area of research offers unique insights into the ageing process and the potential for screening and targeted interventions.

【 授权许可】

   
2013 Baylis et al.; licensee BioMed Central Ltd.

【 图 表 】

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