Stratum corneum hydration inversely correlates with certain serum cytokine levels in the elderly, possibly contributing to inflammaging

Immunity & Ageing

Correspondence

Yoon Kim¹  Peter M. Elias²  Chengzhi Lv³  Li Ye⁴  Mao-Qiang Man⁴  Bin Yang⁴  Wenhai Luo⁵  Zhen Wang⁶ 

[1] CRID Center, NeoPharm Co., Ltd, 34037, Daejeon, Republic of Korea;Deparmtnet of Dermatology, University of California San Francisco and Veterans Affairs Medical Center, 94121, San Francisco, CA, USA;Department of Dermatology, Dalian Skin Disease Hospital, 116021, Liaoning, China;Dermatology Hospital, Southern Medical University, 2 Lujing Road, 510091, Guangzhou, Guangdong, China;School of Public Health and Management, Binzhou Medical University, 264003, Shandong, China;The 7Th People’s Hospital of Shenyang, 110003, Liaoning, China;

关键词: Aging;    pH;    Hydration;    Barrier;    Epidermis;    Inflammation;    Inflammaging;    Cytokines;   

DOI  :  10.1186/s12979-023-00331-1

 received in 2022-11-10, accepted in 2023-02-03,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundChronic, low-grade inflammation, also termed ‘inflammaging’, has been linked to the development of some aging-associated disorders. Recent studies suggest that inflammaging is attributable to aging-associated epidermal dysfunction. However, abnormality in which epidermal function contributes to inflammaging is not clear.ObjectiveWe delineated the correlation of epidermal functions with circulating levels of proinflammatory cytokines in the elderly.MethodsBlood sample was collected from a total of 255 participants aged ≥ 65 years. Epidermal biophysical properties were measured on the left forearm and the right shin. Serum cytokine levels were measured by Multiplex Luminex Assays.ResultsNeither skin surface pH nor transepidermal water loss rates (TEWL) correlated with serum cytokine levels except TEWL on the right shin for TNFa (p < 0.05). In contrast, stratum corneum hydration levels on both the forearm and the shin correlated negatively with serum cytokine levels (p < 0.05).ConclusionReduced stratum corneum hydration likely contributes to inflammaging.

【 授权许可】

CC BY   
© The Author(s) 2023