Urinary biomarker N-acetyl-β-D-glucosaminidase can predict severity of renal damage in diabetic nephropathy

Journal of Diabetes & Metabolic Disorders

Mohamed Saad²  Almokadem Tamer¹  Nashwa Noreldin¹  Gehan Sheira¹ 

[1] Department of Internal Medicine, College of Medicine, University of Tanta, Tanta, Egypt;Clinical Pathology, College of Medicine, University of Tanta, Tanta, Egypt

关键词: Albuminurea;    Diabetic nephropathy;    NAG;   

Others  :  1133294
DOI  :  10.1186/s40200-015-0133-6

 received in 2014-10-25, accepted in 2015-02-05,  发布年份 2015

【 摘 要 】

Background

Diabetic nephropathy is a clinical diagnosis where proteinuria is present in a patient with diabetes. Early intervention can significantly improve the prognosis. However, imprecision of the currently available biomarkers have impaired effective therapies in a timely manner. Urinary N-acetyl-β-D-glucosaminidase (NAG) is excreted in abnormally high amounts in many renal diseases. The aim of this study was to evaluate urinary NAG as an early biomarker in detection of diabetic nephropathy and whether it parallels the severity of kidney damage in different stages of diabetic nephropathy.

Methods

Fifty patients with type 2 DM were classified into 3 groups (normoalbuminurea, microalbuminurea and macroalbuminurea) and 10 healthy subjects served as a control group. Urinary NAG, albumin and creatinine were measured. Blood urea, serum creatinine, serum albumin, total proteins, serum cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), fasting and postprandial blood glucose, HbA1c and creatinine clearance were measured for all subjects.

Results

All diabetic patients had a significantly higher level of urinary NAG compared to control. NAG value increased in parallel with the severity of renal involvement.

Conclusion

Urinary NAG expresses the degree of renal impairment in diabetic nephropathy.

【 授权许可】

   
2015 Sheira et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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