Preventive role of green tea catechins from obesity and related disorders especially hypercholesterolemia and hyperglycemia

Journal of Translational Medicine

Muhammad Zia-Ul-Haq¹  Vincenzo De Feo²  Saikat Dewanjee³  Shakeel Ahmad⁴  Zarina Mushtaq⁶  M Tauseef Sultan⁵  Masood Sadiq Butt⁷  Rabia Shabir Ahmad⁶ 

[1] The Patent Office, Karachi, Pakistan;Department of Pharmacy, University of Salerno, Fisciano, Salerno 84084, Italy;Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India;Department of Agronomy, Bahauddin Zakariya University, Multan, Pakistan;Department of Food Science and Technology, Bahauddin Zakariya University, Multan, Pakistan;Department of Food Science, Nutrition and Home Economics, Govt College University Faisalabad, Faisalabad, Pakistan;National institute of Food Science and Technology, University of Agriculture Faisalabad, Faisalabad, Pakistan

关键词: Hyperglycemia;    Hypercholesterolemia;    EGCG;    Catechins;    Functional drink;    Green tea;   

Others  :  1137565
DOI  :  10.1186/s12967-015-0436-x

 received in 2015-01-15, accepted in 2015-02-12,  发布年份 2015

【 摘 要 】

Background

During the last few years, scientific investigations have proposed diet based regimens to prevent several health ailments including obesity, hypercholesterolemia and diabetes. In this regard, a promising tool is the use of functional foods/nutraceuticals. Present research project was an attempt to explore nutraceutical worth of locally grown green tea variety (Qi-Men) against lifestyle related disorders.

Methods

Functional drinks (T₂ and T₃) were prepared by adding catechins and epigallocatechin gallate (EGCG) @ 550 mg/500 mL and compared with control (T₁). These functional drinks were tested in experimental rats modeling (Sprague Dawley). Based on diets, four studies were conducted i.e. trial-I (normal diet), trial-II (high cholesterol diet), trial-III (high sucrose diet), trial-IV (high cholesterol + high sucrose diet). Rats were monitored daily for their feed and drink intake while body weight was measured on weekly basis. After period of 56 days rats were sacrificed and evaluated their serum lipid (cholesterol, LDL and HDL), glucose and insulin levels.

Results

Results for feed consumption by rats revealed that highest feed intake was recorded in group provided control drink than other groups. However, non significant differences were noted among all groups for drink consumption. Functional drinks resulted in significant reduction in body weight with maximum lowering noted in trial-II and III i.e. 10.73 to 8.49% and 10.12 to 10.49%, respectively. Likewise, cholesterol and LDL were substantially reduced with 14.42% decrease observed in trial-IV and 30.43% in trial-II, respectively. Furthermore, serum glucose and insulin levels were also lowered significantly in the trial-III and IV while in trial-I and II differences were non-significant. In contrast to lipid profile, experimental drink containing EGCG reduced the trait better than catechins based functional drink.

Conclusions

The drinks supplemented with catechins and EGCG are effective against obesity, hypercholesterolemia and hyperglycemia.

【 授权许可】

   
2015 Ahmad et al.; licensee BioMed Central.

【 图 表 】

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