Expression and clinical significance of HSPA2 in pancreatic ductal adenocarcinoma

Diagnostic Pathology

Hongyi Zhang¹  Cheng Wang¹  Yalin Kong¹  Chengli Liu¹  Hongli Gao²  Hui Zhang¹ 

[1] Department of Hepatobiliary Surgery, Air Force General Hospital of PLA, Beijing 100142, China;Department of Oncology, the fourth people’s hospital of Jinan, Jinan 250031, China

关键词: Prognosis;    Overall survival;    Pancreatic cancer;    HSPA2;   

Others  :  1150271
DOI  :  10.1186/s13000-015-0253-9

 received in 2014-12-07, accepted in 2015-03-17,  发布年份 2015

【 摘 要 】

Background

It has been shown that heat shock-related 70-kDa protein 2 (HSPA2), a member of the HSP70 family of heat shock proteins, is important for cancer cell growth and metastasis. However, the status of HSPA2 expression and its prognostic significance in pancreatic cancer remain unknown.

Methods

Quantitative reverse transcriptase ploymerase chain reaction (qRT-PCR) was applied to examine HSPA2 messenger RNA (mRNA) expression in 104 pairs of pancreatic cancer tissues and adjacent noncancerous tissues. Statistical analyses were applied to evaluate the diagnostic value and associations of HSPA2 expression with clinicopathological characteristics.

Results

HSPA2 mRNA was significantly overexpressed in pancreatic cancer tissues (3.9 ± 0.8) than in adjacent normal tissues (1.1 ± 0.4) (P < 0.001). Clinicopathological analysis showed that HSPA2 expression was significantly correlated with tumor size (P = 0.024), histological differentiation (P = 0.012), TNM stage (P = 0.006), lymph node metastasis (P = 0.043) and serum CA19-9 level (P = 0.046). Moreover, patients with higher HSPA2 expression levels had shorter overall survival time than those with lower HSPA2 expression levels (P = 0.019). Furthermore, Cox regression analyses showed that HSPA2 expression was an independent predictor of overall survival (P = 0.011).

Conclusions

Our results suggest that overexpression of HSPA2 in pancreatic cancer is associated with aggressive progression and poor prognosis and that HSPA2 may be served as a prognostic marker.

Virtual slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5988744821527257 webcite.

【 授权许可】

   
2015 Zhang et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

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