The concentration of D-dimers in portal blood positively correlates with overall survival in patients with non-resectable pancreatic cancer

World Journal of Surgical Oncology

Correspondence

Grazyna Poznanska¹  Piotr Hogendorf²  Aleksander Skulimowski²  Siri Øvereng Juliebø²  Janusz Strzelczyk²  Adam Durczynski²  Dariusz Szymanski²  Konrad Marski²  Anna Kumor³ 

[1] Department of Anaesthesiology and Intensive Care, Barlicki Teaching Hospital, Lodz, Poland;Department of General and Transplant Surgery, Barlicki Teaching Hospital, Medical University of Lodz, Kopcinskiego Street 22, 90-153, Lodz, Poland;Department of Pulmonology and Allergy, Barlicki Teaching Hospital, Medical University of Lodz, Lodz, Poland;

关键词: Pancreatic cancer;    D-dimers;    Portal blood;    Overall survival;   

DOI  :  10.1186/s12957-017-1291-4

 received in 2017-06-30, accepted in 2017-12-05,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundSeveral recent studies provide evidence that D-dimer (DD) concentration in peripheral blood correlates negatively with overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC). Contrarily, there are recent evidence indicating that preoperative plasma fibrinogen, but not D-dimer might represent a prognostic factor in non-metastatic gastrointestinal cancers.MethodsIn a single-center prospective study, we enrolled 62 patients undergoing surgery for pathologically confirmed PDAC without detectable venous thrombosis. Intraoperatively, the sample of the blood from the portal vein was obtained. DD concentration in these samples was measured. Patients were followed postoperatively until time of death from any cause.ResultsWe found that OS for patients with portal blood DD values above 2700 (ng/mL) (n = 22 from 62 patients) was higher by 158% than that for the patients (n = 42) with DD values ≤ 2700 (416 days versus 161 days, p = 0.05). On the contrary to the studies investigating DD concentration in peripheral blood, we have found that patients with higher DD level in the portal vein had longer mean OS than patients with lower ones.ConclusionsFurther investigation is necessary both to confirm our results in a larger patient population and to elucidate the mechanism for the correlation between portal blood D-dimer concentrations and survival time. Along with other authors, we conclude that portal circulation is characterized by unique, biological environment that requires further evaluation.

【 授权许可】

CC BY   
© The Author(s). 2017