Overexpression of HSPA2 is correlated with poor prognosis in esophageal squamous cell carcinoma

World Journal of Surgical Oncology

Chun-Fang Zhang¹  Chao-Jun Duan²  Wei Chen¹  Hang Zhang¹ 

[1] Department of Cardiothoracic Surgery, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, Hunan Province 410008, People’s Republic of China;Medical Science Institute, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, Hunan Province 410008, People’s Republic of China

关键词: Prognosis;    Metastasis;    Clinicopathology;    Esophageal squamous cell carcinoma;    HSPA2;   

Others  :  823807
DOI  :  10.1186/1477-7819-11-141

 received in 2013-03-05, accepted in 2013-06-02,  发布年份 2013

【 摘 要 】

Background

Heat shock-related 70 kDa protein 2 (HSPA2) has been identified as a potential cancer-promoting protein expressed at abnormal levels in a subset of cancers. However, its important role in esophageal squamous cell carcinoma (ESCC) is hardly known by people. The purpose of this study is to assess HSPA2 expression and to explore its role in ESCC.

Methods

Thirty ESCC samples, paired adjacent non-cancerous tissues and normal esophageal tissues, were collected for HSPA2 detection by quantitative RT-PCR (qRT-PCR) and western blotting. Additionally, the expression of HSPA2 in ESCC and adjacent non-cancerous tissues from 120 patients was analyzed by immunohistochemistry, and correlated with clinicopathological parameters and patients’ outcome.

Results

HSPA2 mRNA and protein were overexpressed in ESCC tissues. Overexpression of HSPA2 was significantly associated with primary tumor, TNM stage, lymph node metastases and recurrence, respectively (all, P <0.05). Kaplan-Meier curves showed that elevated HSPA2 expression was associated with shorter disease-free survival and overall survival in ESCC patients. Cox multivariate regression analysis revealed that overexpression of HSPA2 was an independent prognostic factor in disease-free survival and overall survival for ESCC patients (hazard ratio was 2.115 and 2.210, respectively, P <0.05).

Conclusions

Our findings demonstrate that overexpression of HSPA2 may contribute to the malignant progression of ESCC and present a novel prognostic indicator for ESCC patients.

【 授权许可】

   
2013 Zhang et al.; licensee BioMed Central Ltd.

【 图 表 】

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