Health-related quality of life and tuberculosis: a longitudinal cohort study

Health and Quality of Life Outcomes

Kevin Schwartzman³  Ashley Wynne³  Bilkis Vissandjée²  Claudia Vadeboncoeur³  Dick Menzies³  Allison Leavens³  Marek Lalli³  Christina Greenaway¹  Andrea Benedetti⁵  Sara Ahmed⁴  Melissa Bauer⁵ 

[1] Division of Infectious Diseases and Clinical Epidemiology, Sir Mortimer B. Davis Jewish General Hospital, Montreal, QC, Canada;Faculté des sciences infirmières – School of Nursing, Université de Montréal, Montreal, QC, Canada;Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, QC, Canada;School of Physical and Occupational Therapy, McGill University, Montreal, QC, Canada;Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada

关键词: Linear mixed model regression;    SF-36;    Health-related quality of life;    Tuberculosis;   

Others  :  1209236
DOI  :  10.1186/s12955-015-0250-4

 received in 2014-09-26, accepted in 2015-04-24,  发布年份 2015

【 摘 要 】

Background

Active tuberculosis (TB) disease can impose substantial morbidity, while treatment for latent TB infection (LTBI) has frequent side effects. We compared health-related quality of life (HRQOL) between persons diagnosed and treated for TB disease, persons treated for LTBI, and persons screened but not treated for TB disease or LTBI, over one year following diagnosis/initial assessment.

Methods

Participants were recruited at two hospitals in Montreal (2008–2011), and completed the Short Form-36 version 2 (SF-36) at baseline, and at 1, 2, 4, 6, 9, and 12 months thereafter. Eight domain scores and physical and mental component summary (PCS and MCS, respectively) scores were calculated from responses. Linear mixed models were used to compare mean scores at each evaluation and changes in scores over consecutive evaluations, among participants treated for TB disease and those treated for LTBI, each compared to the control group.

Results

Of the 263 participants, 48 were treated for TB disease, 105 for LTBI, and 110 were control participants. Fifty-four percent were women, mean age was 35 years, and 90% were foreign-born. Participants treated for TB disease reported significantly worse mean scores at baseline compared to control participants (mean PCS scores: 50.0 vs. 50.7; mean MCS scores: 46.4 vs. 51.1), with improvement in mean MCS scores throughout the study period. Scores reported by participants treated for LTBI and control participants were comparable throughout the study.

Conclusion

TB disease is associated with decrements in HRQOL as measured by the SF-36. This is most pronounced during the weeks after diagnosis and treatment initiation, but is no longer evident after two months.

【 授权许可】

   
2015 Bauer et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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