Altered glucose disposition and insulin sensitivity in peri-pubertal first-degree relatives of women with polycystic ovary syndrome

International Journal of Pediatric Endocrinology

David Geller¹  Svetlana Ten⁴  Michael Rosenbaum⁵  Maria Isabel Hernandez³  Jean-Patrice Baillargeon⁶  Revi Mathew²  Shahid Malik⁴  Amrit Bhangoo⁴  Sonal Bhandari⁴  Sunil Sinha⁴  Radhika Purushothaman⁴  Andrey Kolesnikov⁴  Nouhad Raissouni⁴ 

[1] Department of Pediatrics, Division of Pediatric Endocrinology, Cedars-Sinai Medical Center, David Geffen- University of California, Los Angeles School of Medicine, 8700 Beverly Blvd. Room 4220 North Tower, Los Angeles, CA, 90048, USA;Department of Pediatrics, Division of Pediatric Endocrinology, Vanderbilt University School of Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt, 11134A Doctors' Office Tower, 2200 Children's Way, Nashville, TN, 37232-9170, USA;Departments of Pediatrics, Endocrinologa Infantil, Instituto de Investigaciones Materno Infantil (IDIMI), Universidad de Chile, Clinica Las Condes Santiago, Chile;Division of Pediatric Endocrinology at Infants and Children's Hospital of Brooklyn at Maimonides & SUNY Downstate Medical Center, 1068 48th St, Brooklyn, NY, 11219, USA;Department of Pediatrics, Division of Pediatric Endocrinology, Children's Hospital of New York-Presbyterian, 622 West 168th Street, PH-5E-522, New York, NY, 10032, USA;Department of Medicine, and Physiology and Biophysics, Division of Endocrinology, University of Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, J1H 5N4, Canada

关键词: Beta cell function;    Diabetes mellitus;    Premature pubarche;    Hyperandrogenemia;    Anovulation;    Insulin sensitivity;    Insulin resistance;    PCOS;   

Others  :  813522
DOI  :  10.1186/1687-9856-2012-14

 received in 2012-01-26, accepted in 2012-04-23,  发布年份 2012

【 摘 要 】

Background

First-degree relatives (FDRs) of women with PCOS are at increased risk for impaired insulin sensitivity and diabetes mellitus. Glucose tolerant FDR have evidence of insulin resistance and hyperinsulinemia prior to emergence of frank PCOS.

Aim

To study insulin dynamics parameters in the early adolescent FDR of women with PCOS.

Methods

This is a cross-sectional study involving 18 adolescents whose mothers or sisters had been diagnosed with PCOS and 21 healthy, age-matched control adolescents without FDR. Subjects underwent anthropometric measurements, steroid profiling and frequently sampled Intravenous Glucose Tolerance Test (IVGTT), Homeostasis Model Assessment (HOMA) index, Glucose Disposal Index (GDI), Acute Insulin Response (AIR) and Quantitative insulin sensitivity check index (QUICKI) were derived from IVGTT results.

Results

FDRs showed significantly higher mean HOMA and lower GDI. There were no differences in mean age or BMI Z-score between the cohorts. No differences in sex steroids or AIR were identified between groups.

Conclusion

Female adolescent FDR of women with PCOS have higher HOMA index and lower QUICKI, reflecting altered insulin sensitivity and lower GDI reflecting poorer beta-cell function. The presence of multiple risk factors for type 2 diabetes suggests that aggressive screening of the early adolescent FDR of women with PCOS is indicated.

【 授权许可】

   
2012 Raissouni et al.; licensee BioMed Central Ltd.

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