Regulation of microRNAs by epigenetics and their interplay involved in cancer

Journal of Experimental & Clinical Cancer Research

Ya Cao¹  Zigang Dong²  Ann M Bode²  Yongguang Tao¹  Xinfang Yu¹  Xiaoyan Chen¹  Xiaolan Liu¹ 

[1] Molecular Imaging Center, Central South University, Changsha, Hunan 410078, China;The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA

关键词: Cancer;    Histone modification;    DNA methylation;    Epigenetic;    microRNA;   

Others  :  814130
DOI  :  10.1186/1756-9966-32-96

 received in 2013-10-21, accepted in 2013-11-14,  发布年份 2013

【 摘 要 】

Similar to protein-coding genes, miRNAs are also susceptible to epigenetic modulation. Although numerous miRNAs have been shown to be affected by DNA methylation, the regulatory mechanism of histone modification on miRNA is not adequately understood. EZH2 and HDACs were recently identified as critical histone modifiers of deregulated miRNAs in cancer and can be recruited to a miRNA promoter by transcription factors such as MYC. Because miRNAs can modulate epigenetic architecture and can be regulated by epigenetic alteration, they could reasonably play an important role in mediating the crosstalk between epigenetic regulators. The complicated network between miRNAs and epigenetic machineries underlies the epigenetic–miRNA regulatory pathway, which is important in monitoring gene expression profiles. Regulation of miRNAs by inducing epigenetic changes reveals promising avenues for the design of innovative strategies in the fight against human cancer.

【 授权许可】

   
2013 Liu et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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