期刊论文

【摘要】

Silicosis is one of the most severe occupational diseases worldwide and is characterized by silicon nodules and diffuse pulmonary fibrosis. However, specific treatments for silicosis are still lacking at present. Therefore, elucidating the pathogenesis of silicosis plays a significant guiding role for its treatment and prevention. The occurrence and development of silicosis are accompanied by many regulatory mechanisms, including epigenetic regulation. The main epigenetic regulatory mechanisms of silicosis include DNA methylation, non-coding RNA (ncRNA), and histone modifications. In recent years, the expression and regulation of genes related to silicosis have been explored at epigenetic level to reveal its pathogenesis further, and the identification of aberrant epigenetic markers provides new biomarkers for prediction and diagnosis of silicosis. Here, we summarize the studies on the role of epigenetic changes in the pathogenesis of silicosis to give some clues for finding specific therapeutic targets for silicosis.

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CC BY
© The Author(s) 2022

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Clinical Epigenetics
The emerging role of epigenetic regulation in the progression of silicosis
Review
Haoyu Yin¹ Yingdie Zhang¹ Yuxin Yao¹ Jixuan Ma¹ Yujia Xie¹ Pei Gu¹ Weihong Chen¹ Wei Li²
[1] Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, China;Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, China;Key Lab of Environment and Health, School of Public Health, Xuzhou Medical University, 221004, Xuzhou, Jiangsu, China;
关键词: Silicosis; Epigenetic; DNA methylation; ncRNA; Histone modification;
DOI : 10.1186/s13148-022-01391-8
received in 2022-08-04, accepted in 2022-11-30, 发布年份 2022
来源: Springer
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