Cardiovascular Diabetology | |
Impact of long-term steroid therapy on epicardial and pericardial fat deposition: a cardiac MRI study | |
Simon Greulich3  Heiko Mahrholdt3  M. Dominik Alscher4  Udo Sechtem3  Niko Braun4  Maik Backes1  Stefan Birkmeier3  Joerg Henes2  Joerg Latus4  Daniel Kitterer4  | |
[1] Department of Radiology, Robert-Bosch-Medical Center, Auerbachstrasse 110, Stuttgart, 70376, Germany;Division of Rheumatology, Department of Internal Medicine II, Universitätsklinik Tübingen, Tübingen, Germany;Department of Cardiology, Robert-Bosch-Medical Center, Auerbachstrasse 110, Stuttgart, 70376, Germany;Division of Nephrology, Department of Internal Medicine, Robert-Bosch-Medical Center, Auerbachstrasse 110, Stuttgart, 70376, Germany | |
关键词: Rheumatic disorder; Steroid therapy; Pericardial fat; Epicardial fat; Cardiac MRI; | |
Others : 1228715 DOI : 10.1186/s12933-015-0289-x |
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received in 2015-08-14, accepted in 2015-09-11, 发布年份 2015 | |
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【 摘 要 】
Background
Increased cardiac fat has been identified as a risk factor for coronary artery disease. Metabolic syndrome is associated with increased cardiac fat deposition. Steroids are known to imitate some effects of metabolic syndrome and are frequently used in patients with rheumatic disorders. Primary aim was to evaluate the impact of long-term steroid use on cardiac fat deposition in patients with rheumatic disorders. In addition, we sought to investigate if this effect might be dose-dependent.
Methods
Patients were enrolled as follows: (1) rheumatic disorder; and (2) long-term steroid therapy, and (3) underwent cardiovascular magnetic resonance (CMR) imaging. Patients were stratified in a high-dose (>7.5 mg prednisone equivalent/day for at least 6 months) and a low-dose steroid group (<7.5 mg prednisone equivalent/day) and compared to steroid-naïve controls without rheumatic disorders.
Results
122 patients were included (n = 61 steroid patients, n = 61 controls). N = 36 were classified as high-dose, n = 25 as low-dose steroid group. Steroid patients showed larger epicardial 5.7 [3.5–9.1] cm 2and pericardial 13.0 [6.1–26.8] cm 2areas of fat than controls 4.2 [1.3–5.8] cm 2 /6.4 [1.6–15.4] cm 2 , p < 0.001, p < 0.01, respectively. High-dose steroid patients had more epi- and pericardial fat both than controls: 7.2 [4.2–11.1] cm 2vs. 4.4 [1.0-6.0] cm 2 , p < 0.001; 18.6 [8.9–38.2] cm 2vs. 10.7 [4.7–26.8] cm 2 , p < 0.05, and patients in the low-dose steroid group (p < 0.01, p < 0.001, respectively).
Conclusion
The present data suggest increased cardiac fat deposition in steroid-treated patients with rheumatic disorders. Furthermore, this accumulation of cardiac fat seems to be dose-dependent, pointing towards a cumulative effect of steroids.
【 授权许可】
2015 Kitterer et al.
【 预 览 】
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