Cardiac steatosis and left ventricular function in men with metabolic syndrome

Journal of Cardiovascular Magnetic Resonance

Kirsi Lauerma¹  Nina Lundbom²  Marja-Riitta Taskinen³  Markku S Nieminen³  Reijo Sirén⁴  Antti Hakkarainen²  Jesper Lundbom²  Markku O Pentikäinen³  Marit Granér³  Kristofer Nyman² 

[1] Department of Radiology, HUS Medical Imaging Center, Helsinki University Central Hospital and University of Helsinki, Stenbäckinkatu 11, BOX 281, Helsinki FI-00029 HUS, Finland;Department of Radiology, HUS Medical Imaging Center, Helsinki University Central Hospital and University of Helsinki, Haartmaninkatu 4, BOX 340, FI-00029 HUS, Finland;Heart and Lung Center, Division of Cardiology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland;Department of General Practice and Primary Health Care, Health Care Centre of City of Helsinki and University of Helsinki, Helsinki, Finland

关键词: Cardiac steatosis;    Pericardial fat;    Epicardial fat;    Myocardial triglyceride content;    Diastolic dysfunction;    Obesity;    Metabolic syndrome;    Proton magnetic resonance spectroscopy;    Cardiovascular magnetic resonance;   

Others  :  802128
DOI  :  10.1186/1532-429X-15-103

 received in 2013-05-22, accepted in 2013-11-05,  发布年份 2013

【 摘 要 】

Background

Ectopic accumulation of fat accompanies visceral obesity with detrimental effects. Lipid oversupply to cardiomyocytes leads to cardiac steatosis, and in animal studies lipotoxicity has been associated with impaired left ventricular (LV) function. In humans, studies have yielded inconclusive results. The aim of the study was to evaluate the role of epicardial, pericardial and myocardial fat depots on LV structure and function in male subjects with metabolic syndrome (MetS).

Methods

A study population of 37 men with MetS and 38 men without MetS underwent cardiovascular magnetic resonance and proton magnetic spectroscopy at 1.5 T to assess LV function, epicardial and pericardial fat area and myocardial triglyceride (TG) content.

Results

All three fat deposits were greater in the MetS than in the control group (p <0.001). LV diastolic dysfunction was associated with MetS as measured by absolute (471 mL/s vs. 667 mL/s, p = 0.002) and normalized (3.37 s^-1 vs. 3.75 s^-1, p = 0.02) LV early diastolic peak filling rate and the ratio of early diastole (68% vs. 78%, p = 0.001). The amount of epicardial and pericardial fat correlated inversely with LV diastolic function. However, myocardial TG content was not independently associated with LV diastolic dysfunction.

Conclusions

In MetS, accumulation of epicardial and pericardial fat is linked to the severity of structural and functional alterations of the heart. The role of increased intramyocardial TG in MetS is more complex and merits further study.

【 授权许可】

   
2013 Nyman et al.; licensee BioMed Central Ltd.

【 图 表 】

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