SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism

Genome Integrity

Kurt W Kohn¹  Mirit I Aladjem¹  Augustin Luna² 

[1] Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA;Bioinformatics Program, Boston University, Boston, MA 02215, USA

关键词: Circadian rhythms;    DNA damage repair;    Transcriptional regulation;    Post-translational modifications;    Nicotinamide Adenine Dinucleotide (NAD+) competition;    Metabolism;    Poly-(ADP) polymerases;    PARP1;    Sirtuins;    SIRT1;   

Others  :  814596
DOI  :  10.1186/2041-9414-4-6

 received in 2013-08-14, accepted in 2013-12-02,  发布年份 2013

【 摘 要 】

An intricate network regulates the activities of SIRT1 and PARP1 proteins and continues to be uncovered. Both SIRT1 and PARP1 share a common co-factor nicotinamide adenine dinucleotide (NAD+) and several common substrates, including regulators of DNA damage response and circadian rhythms. We review this complex network using an interactive Molecular Interaction Map (MIM) to explore the interplay between these two proteins. Here we discuss how NAD + competition and post-transcriptional/translational feedback mechanisms create a regulatory network sensitive to environmental cues, such as genotoxic stress and metabolic states, and examine the role of those interactions in DNA repair and ultimately, cell fate decisions.

【 授权许可】

   
2013 Luna et al.; licensee BioMed Central Ltd.

【 图 表 】

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