Association of LOX-1 gene polymorphisms with cerebral infarction in northern Chinese Han population

Lipids in Health and Disease

Zhi-Yi He¹  Lei Li¹  Rui-Xia Zhu¹  Xu Liu¹ 

[1] Department of Neurology, First Affiliated Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang 110001, Liaoning Province, China

关键词: Atherosclerosis;    Cerebral infarction;    Polymorphisms;    Ox-LDL;    LOX-1;   

Others  :  805336
DOI  :  10.1186/1476-511X-13-55

 received in 2014-01-18, accepted in 2014-03-20,  发布年份 2014

【 摘 要 】

Background

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays an important role in the pathophysiology of atherosclerosis and thrombosis. This study is aimed at evaluating the potential association of 3’-UTR-C188T and G501C in LOX-1 gene with cerebral infarction.

Methods

A total of 386 patients with cerebral infarction and 386 healthy controls were included in the study, which were unrelated Chinese Han population in the Liaoning Province of northern China. The single nucleotide polymorphisms, 3’-UTR-C188T and G501C, were analyzed by polymerase chain reaction–ligation detection reaction method.

Results

The frequencies of CC + GC genotype, GC genotype and C allele of G501C in the patients with cerebral infarction were significantly higher than those in the controls (P < 0.01, P < 0.01, P = 0.04, respectively). The correlation still remained after adjusting for confounding risk factors of cerebral infarction. In addition, no significant association was observed between 3’-UTR-C188T and cerebral infarction.

Conclusions

The study indicated that the G501C variant in LOX-1 gene may be associated with susceptibility to cerebral infarction, independent of other common risk factors, in northern Chinese Han population.

【 授权许可】

   
2014 Liu et al.; licensee BioMed Central Ltd.

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