Diabetology & Metabolic Syndrome | |
ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction | |
Rosario Dominguez Crespo Hirata2  Márcia Martins Silveira Bernik1  Egidio Lima Dorea1  Marcela Correia Sousa2  Cristina Moreno Fajardo2  Mario Hiroyuki Hirata2  Alvaro Cerda3  Tamiris Invencioni Moraes2  Raquel de Oliveira2  | |
[1] University Hospital, University of Sao Paulo, Sao Paulo, Brazil;School of Pharmaceutical Sciences, University Sao Paulo, Av. Prof. Lineu Prestes, 580, 05508-900, Sao Paulo, SP, Brazil;Center of Molecular Biology and Pharmacogenetics, BIOREN-CEGIN, Universidad de La Frontera, Temuco, Chile | |
关键词: Gene polymorphism; Interleukin-6; Adiponectin; Inflammation; Obesity; | |
Others : 1174862 DOI : 10.1186/s13098-015-0027-2 |
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received in 2014-12-05, accepted in 2015-03-23, 发布年份 2015 | |
【 摘 要 】
Background
Polymorphisms in genes encoding adiponectin (ADIPOQ) and interleukin-6 (IL6) have been associated with adiposity and obese-related phenotypes. This study investigated the relationship of ADIPOQ and IL6 gene polymorphisms with pro-inflammatory and cardiometabolic markers in obese patients.
Methods
Anthropometric and body composition parameters were measured in 249 Brazilian subjects (30 to 68 yr). Metabolic and inflammatory markers and adipokines were analyzed in blood samples. ADIPOQ rs2241766 (45 T > G) and IL6 rs1800795 (−174G > C) polymorphisms were analyzed by real-time PCR and PCR-RFLP, respectively.
Results
Type 2 diabetes, hypertension, dyslipidemia and increased values of waist circumference, body fat, leptin, fibrinogen, IL-1β, hsCRP and TNFα were related to obesity (p < 0.05). Multiple linear regression analysis showed a positive correlation between BMI and waist circumference, body fat, leptin, fibrinogen, PAI-1, IL-1β, hsCRP and TNFα values (p < 0.001) but not with adiponectin. Obese group had altered metabolic status, resistance to leptin and insulin, and atherogenic and pro-inflammatory profiles. ADIPOQ and IL6 variants were not directely related to obesity, leptin resistance or alterations in cardiometabolic markers. Individuals carrying ADIPOQ 45G allele (TG + GG genotype) had higher IL-6, IL-1β and TNFα levels than TT genotype carriers (p < 0.05). IL6 -174GG genotype was associated with increased IL-1β levels (p = 0.033).
Conclusion
Obesity is associated with leptin resistance, cardiometabolic alterations and a pro-inflammatory status. Our results are suggestive that ADIPOQ and IL6 polymorphisms contribute to cardiometabolic risk in obese individuals.
【 授权许可】
2015 Oliveira et al.; licensee BioMed Central.
【 预 览 】
Files | Size | Format | View |
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20150425030554217.pdf | 525KB | download | |
Figure 1. | 22KB | Image | download |
【 图 表 】
Figure 1.
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