Sensitization to cereals and peanut evidenced by skin prick test and specific IgE in food-tolerant, grass pollen allergic patients

Clinical and Translational Allergy

Lars K Poulsen¹  Hans-Jørgen Malling¹  Heidi J Schnoor¹  Maria Martens¹ 

[1] Allergy Clinic, Copenhagen University Hospital, Gentofte, Denmark

关键词: grass pollen allergy;    food challenge;    diagnosis;    cross-reaction;    Cereals;   

Others  :  794739
DOI  :  10.1186/2045-7022-1-15

 received in 2011-09-15, accepted in 2011-12-09,  发布年份 2011

【 摘 要 】

Background

The botanical relation between grass and cereal grains may be relevant when diagnosing food allergy to cereals. The aim was to investigate the diagnostic specificity of skin prick test (SPT) and specific immunoglobulin E (sIgE) tests to cereals and peanut in grass pollen allergic subjects without history of, and clinically reactions to foods botanically related to grass.

Methods

70 subjects (41 females; mean age 32 years) and 20 healthy controls (13 females; mean age 24 years) were tested by open food challenge (OFC) with cereals and peanut. SPT and sIgE both with Immulite^® (Siemens) and ImmunoCAP^® (Phadia) to grass and birch pollen, cereals, peanut and bromelain were performed.

Results

Of the 65 OFC-negative subjects 29-46% (SPT, depending on cut-off), 20% (Immulite) and 38% (ImmunoCAP) had positive results to one or more of the foods tested. Controls were negative in all tests. Cross-reactive carbohydrate determinants (CCD) as evidenced by reaction to bromelain could explain only a minority of the measured IgE-sensitizations.

Conclusion

Grass pollen allergic patients with documented food tolerance to cereals and peanut may express significant sensitization. False-positive cereal or peanut allergy diagnoses may be a quantitatively important problem both in routine clinical work and epidemiological studies.

【 授权许可】

   
2011 Martens et al; licensee BioMed Central Ltd.

【 图 表 】

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