Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis

Journal of Neuroinflammation

Patricia L Fernández¹  Deborah Doens² 

[1] Centro de Biología Molecular y Celular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), Edificio 219, Clayton, Ciudad del Saber, República de Panamá;Department of Biotechnology, Acharya Nagarjuna University, Guntur, India

关键词: Receptor;    Microglia;    Inflammation;    Cytokines;   

Others  :  812014
DOI  :  10.1186/1742-2094-11-48

 received in 2013-10-01, accepted in 2014-02-24,  发布年份 2014

【 摘 要 】

Alzheimer’s disease (AD) is a major public health problem with substantial economic and social impacts around the world. The hallmarks of AD pathogenesis include deposition of amyloid β (Aβ), neurofibrillary tangles, and neuroinflammation. For many years, research has been focused on Aβ accumulation in senile plaques, as these aggregations were perceived as the main cause of the neurodegeneration found in AD. However, increasing evidence suggests that inflammation also plays a critical role in the pathogenesis of AD. Microglia cells are the resident macrophages of the brain and act as the first line of defense in the central nervous system. In AD, microglia play a dual role in disease progression, being essential for clearing Aβ deposits and releasing cytotoxic mediators. Aβ activates microglia through a variety of innate immune receptors expressed on these cells. The mechanisms through which amyloid deposits provoke an inflammatory response are not fully understood, but it is believed that these receptors cooperate in the recognition, internalization, and clearance of Aβ and in cell activation. In this review, we discuss the role of several receptors expressed on microglia in Aβ recognition, uptake, and signaling, and their implications for AD pathogenesis.

【 授权许可】

   
2014 Doens and Fernández; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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