Cyclin K goes with Cdk12 and Cdk13

Cell Division

Dalibor Blazek²  Jiri Kohoutek¹ 

[1] Department of Toxicology, Pharmacology and Immunotherapy, Veterinary Research Institute, Hudcova 70, 62100 Brno, Czech Republic;Central European Institute of Technology (CEITEC), Masaryk University, 62500 Brno, Czech Republic

关键词: FANCD2;    FANCI;    ATR;    BRCA1;    Phosphorylation of serine 2;    CTD kinase;    CTD code;    Cyclin L;    P-TEFb;    DNA damage;    Posttranscriptional processing;    Transcription;   

Others  :  811601
DOI  :  10.1186/1747-1028-7-12

 received in 2012-03-25, accepted in 2012-04-18,  发布年份 2012

【 摘 要 】

The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to specific cyclin subunits to form a functional and active cyclin/Cdk complex. This review is focused on Cyclin K, which was originally considered an alternative subunit of Cdk9, and on its newly identified partners, Cdk12 and Cdk13. We briefly summarize research devoted to each of these proteins. We also discuss the proteins' functions in the regulation of gene expression via the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II, contributions to the maintenance of genome stability, and roles in the onset of human disease and embryo development.

【 授权许可】

   
2012 Kohoutek and Blazek; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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