Journal of Translational Medicine | |
Trend of transfusion transmitted infections frequency in blood donors: provide a road map for its prevention and control | |
Jabbar Khan2  Sanaullah Khan3  Sobia Attaullah1  | |
[1] Department of Zoology, Islamia College Peshawar (A Public Sector University), University Campus, Jamrod Road, Peshawar 25120, Khyber Pakhtunkhwa, Pakistan;Department of Biological Sciences, Gomal University, D.I.Khan, Pakistan;Molecular Parasitology and Virology Laboratory, Department of Zoology, Kohat University of Science and Technology, Kohat 26000, Khyber Pakhtunkhwa, Pakistan | |
关键词: Blood donor; Syphilis; HIV; HCV; HBV; TTIs; | |
Others : 1207775 DOI : 10.1186/1479-5876-10-20 |
|
received in 2011-10-03, accepted in 2012-01-31, 发布年份 2012 | |
【 摘 要 】
Background
Transfusion transmitted infections create significant burden on health care system. Donor selection is of paramount importance because infected individuals serve as an asymptomatic reservoir and a potential source of transmission.
Methods
A retrospective study was carried out in healthy blood donors in the Lady Reading Hospital Peshawar, Pakistan over a period of three and a half years i.e., from January 2008 to June 2011, to determine the prevalence of HBV, HCV, HIV and syphilis in order to provide information for relevant polices.
Results
Out of 1,27,828 sample of blood donors, recorded mean prevalence for HBs Ag, anti-HCV, anti-HIV and syphilis was 2.68%, 2.46%, 0.06% and 0.43%, respectively, with an increasing trend in frequencies of transfusion transmitted infections (TTIs).
Conclusions
This study reflects that blood transfusion is one of the leading risk factor of spread of the TTIs, which showed the need and importance of the mandatory screening of these infectious markers in blood donations.
【 授权许可】
2011 Attaullah et al; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
20150530105617675.pdf | 343KB | download | |
Figure 1. | 26KB | Image | download |
【 图 表 】
Figure 1.
【 参考文献 】
- [1]Bhawani Y, Rao PR, Sudhakar V: Seroprevalence of transfusion transmissible infections among blood donors in a tertiary care hospital of Andhra Pradesh. Biol Med 2010, 2(4):45-48.
- [2]Khan S, Attaullah S, Ayaz S, Khan SN, Shams S, Ali I, Bilal M, Siraj S: Molecular epidemiology of HCV among the health care workers of Khyber Pakhtunkhwa. Virol J 2011, 8(1):105. BioMed Central Full Text
- [3]Khan ZT, Asim S, Tariq Z, Ehsan MA, Malik RA, Ashfaq B, Hayat : Prevelence of transfusion transmitted infectious in healthy blood donors in Rawalpindi District, Pakistan: a five year survey. Inter J of Pathology 2007, 5(1):21-25.
- [4]Shah SA, Usman G, Ghazi A, Kristensen S, Sathiakumar N, Memon MA, John R, Vermund SH: Prevalence of syphilis among antenatal clinic attendees in Karachi: imperative to begin universal screening in Pakistan. JPMA 2011, 61:993.
- [5]Manzoor I, Hashmi N, Daud S: Seroprevalence of transfusion transmissible infections (TTIS) in blood donors. Biomedica 2009, 25:154-158.
- [6]Attaullah S, Khan S, Ayaz S, Khan SN, Ali I, Hoti N, Siraj S: Prevalence of HBV and HBV Vaccination Coverage in Health Care Workers of Tertiary Hospitals of Peshawar, Pakistan. Virol J 2011, 8(1):275. BioMed Central Full Text
- [7]Ali SA, Donahue RMJ, Qureshi H, Vermund SH: Hepatitis B and Hepatitis C in Pakistan: prevelence and risk factors. Int J Infec Dis 2009, 13(1):9-19.
- [8]Kassi M, Khanani MR, Khan IA, Ali SH: Safe blood transfusion practices in blood banks of Karachi, Pakistan. Transfusion Med 2011, 21:57-62.
- [9]Waheed Y, Shafi T, Safi SZ, Qadri I: Hepatitis C virus in Pakistan: a systematic review of prevalence, genotypes and risk factors. World J Gastroenterol 2009, 15(45):5647-5653.
- [10]National Blood Policy and Strategic Framework 2008-2012 For Blood Transfusion Services in Pakistan. National AIDS Control Program Ministry of Health, Government of Pakistan [http://www.nbtp.gov.pk/Docs/National%20Blood%20Policy] webcite
- [11]Khan EA, Khokhar N, Malik GJ: Seroprevalence of syphilis in asymptomatic adults seeking employment abroad. Rawal Med J 2004, 29(2):65-67.
- [12]Hakim ST, Kasmi SU, Bagasara O: Seroprevelence B and C Genotypes among young apparently healthy female of Karachi-Pakistan. Libyan J Med 2008, 3:66-70.
- [13]Farooqi JI, Farooqi RJ, Khan N, Mussarat : Frequency of hepatitis B and C in selected groups of population in NWFP, Pakistan. JPMI 2007, 21(3):165-167.
- [14]Khan Z, Raziq F, Aslam N: Prevalence of HIV in blood donors in NWFP. JPMI 2002, 16(2):187-189.
- [15]Bhattacharya P, Chandra PK, Datta S, Banerjee A, Chakravarty R: Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005: exploratory screening reveals high frequency of HBV infection. World J Gastroenterol 2007, 13(27):3730-3733.
- [16]Meena M, Jindal T, Hazarika A: Prevalence of hepatitis B virus and hepatitis C virus among blood donors at a tertiary care hospital in India: a five-year study. Transfusion 2011, 51:198-202.
- [17]Jafri W, Jafri N, Yakoob J, Islam M, Tirmizi FA, Jafar T, Akhtar S, Hamid S, Shah HA, Nazmi SQ: Hepatitis B and C: prevalence and risk factors associated with seropositivity among children in Karachi Pakistan. BMC Infect Dis 2006, 6:101. BioMed Central Full Text
- [18]Resende VL, Abreu MH, Paiva SM, Teixeira R, Pordeus SA: Factors associated with seroprevalence of hepatitis C among dentists at a large Brazilian city. Virol J 2009, 6:228. BioMed Central Full Text