SETIL: Italian multicentric epidemiological case–control study on risk factors for childhood leukaemia, non hodgkin lymphoma and neuroblastoma: study population and prevalence of risk factors in Italy

Italian Journal of Pediatrics

Alessandro Polichetti^1,12  Serena Risica^1,12  Susanna Lagorio³  Riccardo Haupt²  Francesco Forastiere⁶  Rosalia Maria Valenti^1,17  Maria Valeria Torregrossa^1,17  Veronica Casotto^2,26  Marina Cuttini^1,19  Manuela Chiavarini^2,21  Liliana Minelli^3,33  Paola Mosciatti⁷  Franco Pannelli^2,24  Vittorio Bocchini^1,13  Domenico Franco Merlo^1,16  Gigliola de Nichilo^3,30  Giorgio Assennato^2,28  Erni Guarino^1,18  Egidio Celentano^2,29  Claudia Galassi^3,34  Pierfranco Biddau⁸  Pierluigi Cocco^1,14  Ursula Kirchmayer⁵  Paola Michelozzi⁶  Alessandra Benvenuti¹  Lia Lidia Luzzatto^2,20  Lorenzo Gafà^1,11  Santina Cannizzaro^1,11  Paola Zambon⁹  Carmelo Rizzari⁴  Giuseppe Masera^2,23  Luigi Bisanti^2,22  Alberto Salvan^2,25  Roberto Rondelli^1,10  Alessandra Ranucci^2,27  Lucia Miligi^1,15  Stefano Mattioli^3,32  Corrado Magnani^3,31 

[1] Occupational and Environmental Epidemiology Unit, ISPO Cancer Prevention and Research Institute Firenze, Firenze, Italy;Istituto Giannina Gaslini, Genova, Italy;National Centre for Epidemiology, Surveillance and Health Promotion, National Institute of Health, Rome, Italy;A.O. San Gerardo, Fondazione MBBM, Monza, Italy;Dipartimento Epidemiologia Regione Lazio, Roma, Italy;UOC Epidemiologia Ambientale, Dipartimento Epidemiologia Regione Lazio, Roma, Italy;Università di Camerino, Dipartimento di Medicina Sperimentale e di Sanità Pubblica, Camerino, Italy;Servizio di Oncoematologia Pediatrica, Ospedale Microcitemico Cagliari, Cagliari, Italy;Registro Tumori del Veneto, Università di Padova, Padova, Italy;Paediatric Oncology-Haematology “Lalla Seràgnoli”, Policlinico S.Orsola-Malpighi, Bologna, Italy;Lega Italiana per la Lotta contro i Tumori Onlus Sez, Provinciale di Ragusa, Ragusa Ibla, Italy;Retired, formerly: Department of Technology and Health, National Institute of Health, Rome, Italy;Epidemiology, Biostatistics and Clinical Trials, IRCCS AOU San Martino- IST Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy;Dipartimento di Sanità Pubblica, Sezione di Medicina del Lavoro, Università di Cagliari, Cagliari, Italy;Occupational and Environmental Epidemiology Unit, ISPO Cancer Prevention and Research Institute, Florence, Italy;Epidemiology, Biostatistics and Clinical Trials, IRCCS Azienda Ospedaliera Universitaria San Martino- IST Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy;Dipartimento di Scienze per la Promozione della Salute Sez.Igiene, Università degli Studi di Palermo, Palermo, Italy;Istituto Nazionale Tumori, Napoli, Italy;Unità di Unità di Ricerca di Epidemiologia Perinatale, Ospedale Pediatrico Bambino Gesù, Roma, Italy;ASL 1 - Torino, Torino, Italy;Dipartimento di Medicina Sperimentale - Sezione di Sanità Pubblica, Università degli Studi di Perugia, Perugia, Italy;Epidemiologia, ASL di Milano, Milano, Italy;Clinica Pediatrica, Università Milano Bicocca, Monza, Italy;Registro Tumori di Macerata e Università di Camerino, Camerino, Italy;Retired, formerly: IASI-CNR, Roma, Italy;IRCCS Burlo Garofolo, Trieste, Italy;Cancer Epidemiology Unit, CPO Piemonte Novara, Novara, Italy;ARPA - Puglia, Bari, Italy;S. O. Analisi e Monitoraggio, ARSAN - Agenzia Regionale Sanitaria della Campania, Napoli, Italy;ASL BT. Dipartimento di Prevenzione, SPESAL, Barletta, Italy;Medical Statistics & Cancer Epidemiology Unit - Department of Translational Medicine, CPO Piemonte and University of Eastern Piedmont, V. Solaroli 17, Novara 28100, Italy;Section of Occupational Medicine, Department of Internal Medicine, Geriatrics and Nephrology, University of Bologna, Bologna, Italy;Dipartimento di Medicina Sperimentale - Sezione di Sanità Pubblica Università degli Studi di Perugia, Perugia, Italy;AOU S.Giovanni Battista e CPO Piemonte, Torino, Italy

关键词: Risk factors;    Epidemiology;    Neuroblastoma;    Non hogdkin lymphoma;    Leukaemia;   

Others  :  1135887
DOI  :  10.1186/s13052-014-0103-5

 received in 2014-07-03, accepted in 2014-12-04,  发布年份 2014

【 摘 要 】

Background

Aetiology of childhood leukaemia and childhood neoplasm is poorly understood. Information on the prevalence of risk factors in the childhood population is limited. SETIL is a population based case–control study on childhood leukaemia, conducted with two companion studies on non-Hodgkin Lymphoma (NHL) and neuroblastoma. The study relies on questionnaire interviews and 50 Hz magnetic field (ELF-MF) indoor measurements. This paper discusses the SETIL study design and includes descriptive information.

Methods

The study was carried out in 14 Italian regions (78.3% of Italian population aged 0–10). It included leukaemia, NHL and neuroblastoma cases incident in 0–10 year olds in 1998–2001, registered by the Italian Association of Paediatric Haematology and Oncology (AIEOP) (accrual over 95% of estimated incidence). Two controls for each leukaemia case were randomly sampled from the Local Health Authorities rolls, matched by gender, birthdate and residence. The same controls were used in NHL and neuroblastoma studies. Parents were interviewed at home on: physical agents (ELF-MF and ionizing radiation), chemicals (smoking, solvents, traffic, insecticides), occupation, medical and personal history of children and parents, infectious diseases, immunizations and associated factors. Occupational exposure was collected using job specific modules. ELF-MF was measured in the main rooms (spot measurement) and close to child’s bed (48 hours measurement).

Results

The study included: 683 leukaemia cases (87% ALL, 13% AnLL), 97 NHL, 155 neuroblastomas, and 1044 controls.

ELF-MF long term measurements were obtained for 61.1% of controls and 81.6% of leukaemia cases; 8.8% of controls were exposed at over 0.1 microTesla (μT), 3.5% and 2.1% at respectively over 0.2 and 0.3 μT. 25% of controls’ fathers had smoked over 10 cigarettes/day during the year of conception, varying according to education and region. Maternal smoking was less common (71.4% did not smoke in pregnancy). Maternal passive smoking during pregnancy was reported by 31.2% of controls; the child’s passive smoking for 28.6%.

Occupational exposure to solvents was estimated in 18.3% of controls’ fathers and 7.7% of mothers. Contact with public was more frequent among mothers (36.1%) than fathers (23.4%).

Conclusions

SETIL represents a data source on exposure of Italian children to a broad array of potential carcinogenic factors.

【 授权许可】

   
2014 Magnani et al.; licensee BioMed Central.

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