SAA1 gene variants and childhood obesity in China

Lipids in Health and Disease

Li Wei¹  Hai-Ju Zhang¹  Ai-Ying Wan¹  Qi-Zhu Tang¹  Xiao Zhang¹ 

[1] Department of Pediatric, RenMin Hospital of Wuhan University, Jie Fang Road, Wuchang district, Wuhan 430060, China

关键词: Childhood;    Obesity;    Serum amyloid A;    Genetic polymorphisms;   

Others  :  829339
DOI  :  10.1186/1476-511X-12-161

 received in 2013-09-18, accepted in 2013-10-05,  发布年份 2013

【 摘 要 】

Background

Obesity increases the risk for insulin resistance and metabolic syndrome in both adults and children. SAA is a member of apolipoprotein and plays an important role in maintaining glucose and lipid homeostasis. The purpose of this study was to assess SAA1 allelic variants with obesity in young school-age children.

Methods

A total of 520 consecutive children ages 5–15 years were recruited. Children were divided based on BMI z score into Obese (OB; BMI z score ≥1.65; n = 253) and non-obese (NOB; n = 267). Four SNPs of the human SAA1 gene (rs12218, rs4638289, rs7131332 and rs11603089) were genotyped by use of polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) method.

Results

Compared to NOB, circulating SAA levels were increased in OB, as were LDL-C, TG and TC concentration. Obese children showed increased frequency of rs12218 and rs4638289 polymorphism compared to control children. There were no differences between OB and NOB for the other 2 polymorphisms. Only the rs4638289 polymorphism showed significant contributions to higher SAA plasma levels.

Conclusions

SAA1 genetic polymorphism was associated with obesity in Chinese children.

【 授权许可】

   
2013 Zhang et al.; licensee BioMed Central Ltd.

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