Associations of genetic polymorphisms of SAA1 with cerebral infarction

Lipids in Health and Disease

Jian-Hua Zhao¹  Li Chang¹  Hai-Qing Yan¹  Sheng-Bo Tao¹  He-Hua Li¹  Bin Yuan¹  Li-Jun Zhang¹ 

[1]Department of Neurology, First Affiliated Hospital of Xinxiang Medical College, Xinxiang, Henan 453100, P R. China

关键词: Cerebral infarction;    Serum amyloid A;    Genetic polymorphisms;   

Others  :  833829
DOI  :  10.1186/1476-511X-12-130

 received in 2013-07-26, accepted in 2013-08-14,  发布年份 2013

【 摘 要 】

Background

Serum amyloid A protein (SAA) is both an inflammatory factor and an apolipoprotein. However, the relation between genetic polymorphisms of SAA and cerebral infarction (CI) remains unclear.

Methods and results

The previously reported 4 Single Nucleotide Polymorphisms (rs12218, rs4638289, rs7131332, and rs11603089) of SAA1 gene were genotyped by TaqMan method in a case–control study including 287 cerebral infarction patients and 376 control subjects. We found rs12218 CC genotype and rs7131332 AA genotype were more frequent among CI patients than among controls (9.76% versus 3.19%, P = 0.001; 32.75% versus 24.20%; p = 0.017; respectively). After adjustment of confounding factors such as sex, age, smoking, drinking, hypertension, diabetes, and lipids profile, the difference remained significant in rs12218 (P < 0.01, OR = 2.106, 95% CI: 1.811–7.121).

Conclusion

Genetic polymorphism of SAA1 may be a genetic maker of cerebral infarction in Chinese.

【 授权许可】

   
2013 Zhang et al.; licensee BioMed Central Ltd.

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