The association of cardiovascular risk factors with saturated fatty acids and fatty acid desaturase indices in erythrocyte in middle-aged Korean adults

Lipids in Health and Disease

Seung-Min Lee¹  So Yeon Jeon²  Seung Rye Kim² 

[1] Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, South Korea;Program of Clinical Nutrition, Graduate School of Human Environmental Sciences, Yonsei University, Seoul, South Korea

关键词: Delta 6 desaturase index;    Delta 9 desaturase index;    Cardiovascular risk;    Erythrocyte;    Fatty acid composition;   

Others  :  1231337
DOI  :  10.1186/s12944-015-0135-x

 received in 2015-08-14, accepted in 2015-10-13,  发布年份 2015

【 摘 要 】

Background

The quality of dietary fats is associated with risk of cardiovascular diseases (CVD). We aimed to investigate the association between fatty acids in erythrocyte membrane phospholipids and CVD risk factors in middle-aged Korean adults.

Methods

Fifty-five middle-aged adults who underwent health examinations were included in this retrospective and cross-sectional study. Anthropometry, serum lipids, clinical parameters, and erythrocyte membrane phospholipid fatty acid data were obtained from a registry.

Results

The proportion of C14:0 and C16:0 was greatly elevated in high quartile groups for triglyceride (TG) and systolic and diastolic blood pressure groups (SBP and DBP) (p = 0.042, p = 0.021, or p = 0.008 respectively) compared to low quartile groups. While C16:1n7 and/or C18:1n9 were positively associated with CVD risk factors, the delta 9 desaturase activity index (D9D) (C18:1n9/C18:0) was only significantly increased in high quartile groups for TG and blood pressures (p = 0.001, p = 0.002 or p = 0.003). Conversely, TG and blood pressures showed inverse relationships with C20:4n6 or D5D (C20:4n6/C20:3n6). C18:3n6 and/or D6D (C18:3n6/C18:2n6) were positively associated with insulin resistance and diabetic parameters. Particularly high D6D was detected in high quartile groups of FBS and insulin (p = 0.016 and p = 0.042). In linear regression analysis, D9D and/or C14:0 + C16:0 were significant contributors to serum TG and blood pressures. D6D was a contributing factor to FBS.

Conclusions

The indices of D9D and D6D from erythrocyte membrane phospholipids and the proportion of saturated fatty acids were increased as the cardiovascular risk factors, including serum TG, blood pressures, and FBS increased their levels (IRB number C2014199 (1396)).

【 授权许可】

   
2015 Kim et al.

【 图 表 】

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