Product activation of human erythrocyte AMP deaminase

FEBS Letters

Vitvitsky, V.M¹  Mosharov, E.V¹  Ataullakhanov, F.I¹ 

[1] Research Center for Hematology, Russian Academy of Medical Sciences, Novozykovskii pr. 4a, Moscow 125167, Russia

关键词: Erythrocyte;    AMP deaminase;    Adenylate metabolism;    Enzyme activation;   

DOI  :  10.1016/S0014-5793(98)01429-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

IMP was found to activate AMP deaminase in crude glucose-depleted human erythrocyte lysates. Activation of the enzyme by IMP is due to prevention of the inhibitory effect of inorganic phosphate. At 1 mM AMP and 2–3 mM phosphate the addition of 2–5 mM IMP accelerates the AMP deamination two to three times.

【 授权许可】

Unknown