A rare primary tumor of the thyroid gland: report a new case of leiomyosarcoma and literature review

Diagnostic Pathology

Amarti Affaf¹  Kaouthar Moumna¹  Ihsane Souaf¹  Hinde El Fatemi¹  Bennani Amal¹ 

[1] Departement of pathology, Hassan II University Hospital, Fez 30000, Morocco

关键词: Medullary carcinoma;    Anaplastic carcinoma;    Thyroid gland;    Primary leiomyosarcoma;   

Others  :  807433
DOI  :  10.1186/1746-1596-8-36

 received in 2012-12-11, accepted in 2013-02-20,  发布年份 2013

【 摘 要 】

Primary leiomyosarcomas of the thyroid gland are extremely rare. we report a case of a 72 year-old women with a painful growing mass of the left neck with skin fistula. The patient underwent a lobectomy. The tumor histology showed spindle-shaped cells arranged in interlacing fascicles that expressed desmine and Hcaldesmone, but were negative for cytokeratins and thyroglobulin. Total body CT scan didnt show any other tumor. The patient died two months after surgery. Primary thyroid leiomyosarcoma may be mistaken for other tumors, such as anaplastic or medullary carcinomas. Therefore, the diagnosis is difficult and requires numerous clinical, radiological, and pathological investigations.

Virtual Slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1917621950869224 webcite

【 授权许可】

   
2013 Amal et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

Figure 4.

Figure 5.

Figure 6.

Figure 7.

Figure 8.

Figure 9.

【 参考文献 】

• [1]Tran LM, Mark R, Meier R, Calcaterra TC, Parker RG: Sarcomas of the head and neck: prognostic factors and treatment strategies. Cancer 1992, 70:169-177.
• [2]Saleh HA, Bo J, John B, Opada A: Utility of immunohistochemical markers in differentiating benign from malignant follicular-derived thyroid nodules. Diagn Pathol 2010, 5:9. (26 January 2010) BioMed Central Full Text
• [3]Qingbin S, Deguang W, Yi L, Changsi L, Changqing F, Xiangmin H, Jianhua L: Diagnostic significance of CK19, TG, Ki67 and galectin-3 expression for papillary thyroid carcinoma in the northeastern region of China. Diagn Pathol 2011, 6:126. (21 December 2011) BioMed Central Full Text
• [4]Dina El D, Ahmed N, Salem A: Application of CD56, P63 and CK19 immunohistochemistry in the diagnosis of papillary carcinoma of the thyroid. Diagn Pathol 2008, 3:5. (6 February 2008) BioMed Central Full Text
• [5]Xiaoqi L, Bing Z, Yulin L, Silverman JF: Follicular thyroid carcinoma invades venous rather than lymphatic vessels. Diagn Pathol 2010, 5:8. (22 January 2010) BioMed Central Full Text
• [6]Thompson LD, Wenig BM, Adair CF, Shmookler BM, Heffess CS: Primary smooth muscle tumors of the thyroid gland. Cancer 1997, 79:579-587.
• [7]Andrion A, Bellis D, Delsedime L: Leiomyoma and neurilemoma: report of two unusual non-epithelial tumours of the thyroid gland. Virchows Archiv Pathol Anat 1988, 413:367-372.
• [8]Akcam T, Oysul K, Birkent H: Leiomyosarcoma of the head and neck: report of two cases and review of the literature. Auris Nasus Larynx 2005, 32:209-212.
• [9]Lin JD, Weng HF, Ho YS: Clinical and pathological characteristics of secondary thyroid cancer. Thyroid 1998, 8:149-153.
• [10]Ordonez NG, El-Naggar AK, Hickey RC: Anaplastic thyroid carcinoma. Immunocytochemical study of 32 cases. Am J Clin Pathol 1991, 96:15-24.
• [11]Just PA, Guillevin R, Capron F: An unusual clinical presentation of a rare tumor of the thyroid gland: report on one case of leiomyosarcoma and review of literature. An of Diag Path 2008, 12:50-56.
• [12]Kamaljeet S, Sharma MC, Deepali J, Rajinder K: Melanotic medullary carcinoma of thyroid – report of a rare case with brief review of literature. Diagn Pathol 2008, 3:2. (11 January 2008) BioMed Central Full Text
• [13]Thompson LD, Wenig BM, Adair CF: Primary smooth muscle tumors of the thyroid gland. Cancer 1997, 79:579-587.
• [14]Adachi M, Wellmann KF, Garcia R: Metastatic leiomyosarcoma in brain and heart. J Pathol 1969, 98:294-296.
• [15]Ozaki O, Sugino K, Mimura T: Primary leiomyosarcoma of the thyroid gland. Surg Today 1997, 27:177-180.