Oncocytic variant of medullary thyroid carcinoma: a rare case of sporadic multifocal and bilateral RET wild-type neoplasm with revision of the literature

Rare Tumors

Armando Bartolazzi²  Claudia Cippitelli²  Angelo Minucci¹  Ettore Capoluongo¹  Gian Luca Rampioni Vinciguerra²  Niccolò Noccioli² 

[1] Laboratory of Clinical Molecular and Personalized Diagnostics, Institute of Biochemistry and Clinical Biochemistry, Catholic University and Foundation, Gemelli Hospital, Rome;Department of Pathology, Sant’Andrea Hospital, University Sapienza of Rome

关键词: Thyroid;    Medullary carcinoma;    Oncocytic variant;    RET;   

DOI  :  10.4081/rt.2016.6537

来源: PAGEPress Publications

【 摘 要 】

Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. However in the Multiple Endocrine Neoplasia Syndrome 2, linked to the point mutation of RET oncogene, multifocal MTCs may also occur. Herein, we report the case of a 75 years old man with a rare form of sporadic multifocal and bilateral OV-MTC expressing wild-type RET gene. The histological and molecular features of this rare entity are presented and discussed with revision of the pertinent literature.

【 授权许可】

Unknown