Primary leiomyosarcoma of the thyroid with concurrent papillary thyroid cancer: a rare case report and a review of literature

Thyroid Research

Case Report

Abdullah Altasan¹  Faisal Alqahtani¹  Mohamed Asiri¹  Lujain Akram Ali²  Faisal Alsarrani³  Saad Alshehri³  Awad Alshahrani⁴  Majed Pharaon⁵ 

[1] College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia;King Abdullah International Medical Research Center, Riyadh, Saudi Arabia;College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia;King Abdullah International Medical Research Center, Riyadh, Saudi Arabia;Department of General Surgery, Ministry of National Guard – Health Affairs, Riyadh, Saudi Arabia;King Abdullah International Medical Research Center, Riyadh, Saudi Arabia;Department of Medicine, Ministry of National Guard – Health Affairs, Riyadh, Saudi Arabia;King Abdullah International Medical Research Center, Riyadh, Saudi Arabia;Department of Pathology and Laboratory Medicine, Ministry of National Guard – Health Affairs, Riyadh, Saudi Arabia;

关键词: Thyroid leiomyosarcoma;    Papillary thyroid cancer;    Primary thyroid soft tissue tumor;    Primary leiomyosarcoma;    Thyroid nodules;   

DOI  :  10.1186/s13044-023-00157-5

 received in 2023-01-23, accepted in 2023-04-14,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundLeiomyosarcoma (LMS) is a soft tissue malignant tumor that has a predilection to the abdominopelvic and limb smooth muscles. LMS of the thyroid is exceptionally rare. Papillary thyroid cancer (PTC) is the most common thyroid malignancy and originates from the thyroid epithelial layer. To our knowledge, the presence of both tumors in the same patient has not been reported previously.Case presentation & literature reviewA 42-year-old woman presented with a progressively enlarging neck mass for a few months. She underwent left thyroid lobectomy, and the histology showed high-grade primary LMS of the thyroid. She subsequently underwent a complete thyroidectomy, which identified a classical PTC on her right lobe.Our comprehensive literature review identified 39 published cases of primary LMS of the thyroid. The average tumor size was 5.88 cm and occurred more in women. The most common presentation was neck mass, followed by compressive symptoms. Recurrence and metastasis were uncommon at 15% and 10–25%, respectively.ConclusionThyroid LMS is a rare malignancy with a worse prognosis than PTC. A thorough workup must be done to rule out metastasis before labeling it as primary thyroid cancer.

【 授权许可】

CC BY   
© The Author(s) 2023

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