Long term effects of cocaine on the heart assessed by cardiovascular magnetic resonance at 3T

Journal of Cardiovascular Magnetic Resonance

Dudley J Pennell⁴  Vicente Belloch⁵  Jose Salazar²  Mirella Gavilan⁵  Begoña Igual⁵  Juan Cosin-Sales³  Carmen Ripoll¹  Alicia M Maceira⁵ 

[1] Addictions Treatment Unit of Campanar, La Fe Hospital, Valencia, Spain;Department of Psychiatry, Consorcio Hospital General, Valencia, CIBERSAM, Spain;Department of Cardiology, Hospital Arnau de Vilanova, Valencia, Spain;NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital & Imperial College, London, UK;Cardiac Imaging Unit, ERESA Medical Center, Valencia, RIC, Spain

关键词: Heart failure;    Magnetic resonance;    Cocaine;   

Others  :  801432
DOI  :  10.1186/1532-429X-16-26

 received in 2013-09-15, accepted in 2014-03-24,  发布年份 2014

【 摘 要 】

Background

Cocaine is an addictive, sympathomimetic drug with potentially lethal effects. The prevalence and features of cocaine cardiotoxicity are not well known. We aimed to assess these effects using a comprehensive cardiovascular magnetic resonance (CMR) protocol in a large group of asymptomatic cocaine users.

Methods

Consecutive (n = 94, 81 males, 36.6 ±7 years), non-selected, cocaine abusers were recruited and had a medical history, examination, ECG, blood test and CMR. The CMR study included measurement of left and right ventricular (LV, RV) dimensions and ejection fraction (EF), sequences for detection of myocardial oedema and late gadolinium enhancement (LGE). Images were compared to a cohort of healthy controls.

Results

Years of regular cocaine use were 13.9 ± 9. When compared to the age-matched healthy cohort, the cocaine abusers had increased LV end-systolic volume, LV mass index and RV end-systolic volume, with decreased LVEF and RVEF. No subject had myocardial oedema, but 30% had myocardial LGE indicating myocardial damage.

Conclusions

CMR detected cardiovascular disease in 71% of this cohort of consecutive asymptomatic cocaine abusers and mean duration of abuse was related to probability of LV systolic dysfunction.

【 授权许可】

   
2014 Maceira et al.; licensee BioMed Central Ltd.

【 图 表 】

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