Long term effects of cocaine on the heart assessed by cardiovascular magnetic resonance at 3T

Journal of Cardiovascular Magnetic Resonance

Research

Carmen Ripoll¹  Begoña Igual²  Alicia M Maceira²  Vicente Belloch²  Mirella Gavilan²  Juan Cosin-Sales³  Jose Salazar⁴  Dudley J Pennell⁵ 

[1] Addictions Treatment Unit of Campanar, La Fe Hospital, Valencia, Spain;Cardiac Imaging Unit, ERESA Medical Center, Valencia, RIC, Spain;Department of Cardiology, Hospital Arnau de Vilanova, Valencia, Spain;Department of Psychiatry, Consorcio Hospital General, Valencia, CIBERSAM, Spain;NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital & Imperial College, London, UK;

关键词: Cocaine;    Magnetic resonance;    Heart failure;   

DOI  :  10.1186/1532-429X-16-26

 received in 2013-09-15, accepted in 2014-03-24,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundCocaine is an addictive, sympathomimetic drug with potentially lethal effects. The prevalence and features of cocaine cardiotoxicity are not well known. We aimed to assess these effects using a comprehensive cardiovascular magnetic resonance (CMR) protocol in a large group of asymptomatic cocaine users.MethodsConsecutive (n = 94, 81 males, 36.6 ±7 years), non-selected, cocaine abusers were recruited and had a medical history, examination, ECG, blood test and CMR. The CMR study included measurement of left and right ventricular (LV, RV) dimensions and ejection fraction (EF), sequences for detection of myocardial oedema and late gadolinium enhancement (LGE). Images were compared to a cohort of healthy controls.ResultsYears of regular cocaine use were 13.9 ± 9. When compared to the age-matched healthy cohort, the cocaine abusers had increased LV end-systolic volume, LV mass index and RV end-systolic volume, with decreased LVEF and RVEF. No subject had myocardial oedema, but 30% had myocardial LGE indicating myocardial damage.ConclusionsCMR detected cardiovascular disease in 71% of this cohort of consecutive asymptomatic cocaine abusers and mean duration of abuse was related to probability of LV systolic dysfunction.

【 授权许可】

Unknown   
© Maceira et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.