Journal of Hematology & Oncology | |
Validation of the M. D. Anderson Symptom Inventory multiple myeloma module | |
Tito R Mendoza2  Charles S Cleeland2  Richard E Champlin3  Valen E Johnson1  Sheeba K Thomas4  Nina D Shah3  Loretta A Williams2  Xin Shelley Wang2  Elisabeth G Vichaya2  Desiree Jones2  | |
[1] Current address: Department of Statistics, Texas A&M University, 525K Blocker, 3143 TAMU, College Station, 77843-3143, Houston, TX, USA;Department of Symptom Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1450, 77030, Houston, TX, USA;Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 423, 77030, Houston, TX, USA;Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 429, 77030, Houston, TX, USA | |
关键词: MDASI; Multiple myeloma; Validation; Assessment; Symptoms; | |
Others : 812628 DOI : 10.1186/1756-8722-6-13 |
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received in 2012-11-27, accepted in 2013-01-31, 发布年份 2013 | |
【 摘 要 】
Background
The symptom burden associated with multiple myeloma (MM) is often severe. Presently, no instrument comprehensively assesses disease-related and treatment-related symptoms in patients with MM. We sought to validate a module of the M. D. Anderson Symptom Inventory (MDASI) developed specifically for patients with MM (MDASI-MM).
Methods
The MDASI-MM was developed with clinician input, cognitive debriefing, and literature review, and administered to 132 patients undergoing induction chemotherapy or stem cell transplantation. We demonstrated the MDASI-MM’s reliability (Cronbach α values); criterion validity (item and subscale correlations between the MDASI-MM and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and the EORTC MM module (QLQ-MY20)), and construct validity (differences between groups by performance status). Ratings from transplant patients were examined to demonstrate the MDASI-MM’s sensitivity in detecting the acute worsening of symptoms post-transplantation.
Results
The MDASI-MM demonstrated excellent correlations with subscales of the 2 EORTC instruments, strong ability to distinguish clinically different patient groups, high sensitivity in detecting change in patients’ performance status, and high reliability. Cognitive debriefing confirmed that the MDASI-MM encompasses the breadth of symptoms relevant to patients with MM.
Conclusion
The MDASI-MM is a valid, reliable, comprehensive-yet-concise tool that is recommended as a uniform symptom assessment instrument for patients with MM.
【 授权许可】
2013 Jones et al; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
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20140709091341243.pdf | 317KB | download | |
Figure 1. | 51KB | Image | download |
【 图 表 】
Figure 1.
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