New approaches to investigating social gestures in autism spectrum disorder

Journal of Neurodevelopmental Disorders

Pendleton Read Montague³  Justin Schwind²  Jian Li¹  Kenneth T Kishida⁴ 

[1] Department of Psychology, New York University, New York, NY, 10003, USA;Department of Athletics, University of South Alabama, Mobile, AL, 36608, USA;Virginia Tech Carilion Research Institute & Department of Physics, Virginia Tech, 2 Riverside Circle, Roanoke, VA, 24018, USA;Human Neuroimaging Laboratory and Computational Psychiatry Unit, Virginia Tech Carilion Research Institute, Roanoke, VA, 24016, USA

关键词: Biomarker;    Functional magnetic resonance imaging;    Computational models;    Game theory;    Reciprocation;    Social exchange;    Autism spectrum disorder;   

Others  :  811867
DOI  :  10.1186/1866-1955-4-14

 received in 2012-02-10, accepted in 2012-04-27,  发布年份 2012

【 摘 要 】

The combination of economic games and human neuroimaging presents the possibility of using economic probes to identify biomarkers for quantitative features of healthy and diseased cognition. These probes span a range of important cognitive functions, but one new use is in the domain of reciprocating social exchange with other humans - a capacity perturbed in a number of psychopathologies. We summarize the use of a reciprocating exchange game to elicit neural and behavioral signatures for subjects diagnosed with autism spectrum disorder (ASD). Furthermore, we outline early efforts to capture features of social exchange in computational models and use these to identify quantitative behavioral differences between subjects with ASD and matched controls. Lastly, we summarize a number of subsequent studies inspired by the modeling results, which suggest new neural and behavioral signatures that could be used to characterize subtle deficits in information processing during interactions with other humans.

【 授权许可】

   
2012 Kishida et al.; licensee BioMed Central Ltd

【 图 表 】

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