Macrophages and angiogenesis: a role for Wnt signaling

Journal of Angiogenesis Research

Christopher C W Hughes²  Andrew C Newman¹ 

[1] The Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, 92697, USA;The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California Irvine, Irvine, CA, 92697, USA

关键词: Wnt;    Angiogenesis;    Macrophage;   

Others  :  801962
DOI  :  10.1186/2045-824X-4-13

 received in 2012-06-23, accepted in 2012-07-13,  发布年份 2012

【 摘 要 】

Macrophages regulate many developmental and pathological processes in both embryonic and adult tissues, and recent studies have shown a significant role in angiogenesis. Similarly, Wnt signaling is fundamental to tissue morphogenesis and also has a role in vascular development. In this review, we summarize recent advances in the field of macrophage-regulated angiogenesis, with a focus on the role of macrophage-derived Wnt ligands. We review data that provide both direct and indirect evidence for macrophage-derived Wnt regulation of physiologic and pathologic angiogenesis. Finally, we propose that Wnt signaling plays a central role in differentiation of tumor associated and wound infiltrating macrophages to a proangiogenic phenotype.

【 授权许可】

   
2012 Newman and Hughes; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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