High serum phosphate and triglyceride levels in smoking women and men with CVD risk and type 2 diabetes

Diabetology & Metabolic Syndrome

Lennart O Bäckman²  Birgitta Törnkvist¹  Lena M Håglin² 

[1] Animal Health Care, Hällnäs 4, Vännäs SE- 911 94, Sweden;Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, UMEÅ SE-901 87, Sweden

关键词: Smoking;    Phosphate;    Gender;    Risk factors;    Obesity;    Glucose intolerance;   

Others  :  804983
DOI  :  10.1186/1758-5996-6-39

 received in 2013-11-06, accepted in 2014-03-07,  发布年份 2014

【 摘 要 】

Background

Both low and high serum phosphate levels may be associated with morbidity and mortality from cardiovascular disease. As smoking increases risk for type 2 diabetes (as shown by dyslipidemia and hyperglycemia), we wanted to study whether smoking and type 2 diabetes were associated with serum phosphate and triglyceride levels independently from other CVD risk factors.

Methods

Upon admittance to the Vindeln Health Education Centre (VHE-centre) for a four-week comprehensive lifestyle intervention, the participants (1408 women and 1096 men) completed a questionnaire that included their smoking habits – current smoker or non-smoker. We used multiple linear regression analyses to investigate the association between smoking and other CVD risk factors with S-P and S-TG levels.

Results

In the non-type 2 diabetes populations, the smokers, compared to the non-smokers, had higher S-P and higher serum triglycerides (S-TG). In women, serum-TG in smokers with type 2 diabetes was higher than in smokers with non-type 2 diabetes. Non-type 2 diabetes patients exhibited an inverse relation between S-Glucose (S-Glu) and S-P and a positive association with S-TG. For men only, an association was seen between age (-) and S-Crea (-) and S-P. For women only, an association was seen between BMI (-) and S-Cholesterol (+) (S-Chol) and S-P.

Conclusions

Compared to non-smokers, smoking women with non-type 2 diabetes and smoking men with type 2 diabetes had a higher level of S-P and S-TG. The association between smoking and S-P and S-TG levels still existed after adjusting for age and CVD risk factors in the multiple linear regression analyses.

Trial registration

The study has been registered as a sub-study to the Lifestyle Intervention Trial no. ISRCTN79355192.

【 授权许可】

   
2014 Håglin et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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