Transient neuromyopathy after bromide intoxication in a dog with idiopathic epilepsy

Irish Veterinary Journal

Henning Christian Schenk¹  Thomas Bilzer²  Andrea Tipold¹  Sonja Steinmetz¹ 

[1] Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Bünteweg 9, Hannover, 30559, Germany;Institute of Neuropathology, University of Düsseldorf, Moorenstrasse 5, Duesseldorf, 40225, Germany

关键词: Potassium bromide;    Myopathy;    Lower motor neuron signs;    Intoxication;    Epilepsy;   

Others  :  810871
DOI  :  10.1186/2046-0481-65-19

 received in 2011-11-30, accepted in 2012-11-19,  发布年份 2012

【 摘 要 】

A seven-year old Australian Shepherd, suffering from idiopathic epilepsy under treatment with phenobarbitone and potassium bromide, was presented with generalised lower motor neuron signs. Electrophysiology and muscle-nerve biopsies revealed a neuromyopathy.

The serum bromide concentration was increased more than two-fold above the upper reference value.

Clinical signs disappeared after applying diuretics and reducing the potassium bromide dose rate. This is the first case report describing electrophysiological and histopathological findings associated with bromide induced lower motor neuron dysfunction in a dog.

【 授权许可】

   
2012 Steinmetz et al.; licensee BioMed Central Ltd.

【 图 表 】

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