Relationship between serum osteocalcin level and carotid intima-media thickness in a metabolically healthy Chinese population

Cardiovascular Diabetology

Weiping Jia¹  Yuqian Bao¹  Xiaoping Pan¹  Yiting Xu¹  Qin Xiong¹  Yaping Hao¹  Xiaojing Ma¹  Yuqi Luo¹ 

[1] Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, 600 Yishan Road, Shanghai 200233, China

关键词: Atherosclerosis;    Metabolically healthy;    Carotid intima-media thickness;    Osteocalcin;   

Others  :  1216826
DOI  :  10.1186/s12933-015-0245-9

 received in 2015-04-24, accepted in 2015-06-10,  发布年份 2015

【 摘 要 】

Background

The relationship between osteocalcin and atherosclerosis remains unclear. This might be due to different degrees of confounding from factors that are associated with serum osteocalcin level, such as metabolic-related variables. This study aimed to investigate the relationship between serum osteocalcin level and carotid intima-media thickness (C-IMT) in a metabolically healthy population.

Methods

A total of 476 subjects with normal values for weight, glucose tolerance, blood pressure, and lipids (age range, 20–75 years; 155 men, 201 premenopausal women, 120 postmenopausal women) from the Shanghai Obesity Study were recruited for this cross-sectional study. Subjects with a history of cardiovascular disease or carotid plaque were excluded. C-IMT was measured by ultrasonography. Serum osteocalcin level was assessed by an electrochemiluminescence immunoassay.

Results

Median C-IMT in the entire study population was 0.55 mm with an interquartile range of 0.50–0.60 mm. C-IMT in premenopausal women was significantly lower than that in men and postmenopausal women (all P < 0.001). The median (interquartile range) of serum osteocalcin level in the entire population was 17.02 (13.31–21.47) ng/mL. Serum osteocalcin level in postmenopausal women was significantly higher than that in men and premenopausal women (all P < 0.001), while the level of serum osteocalcin in men was also significantly higher than that in premenopausal women (P < 0.001). No significant correlation was found between C-IMT and serum osteocalcin level in either men or postmenopausal women. There was a significant, inverse correlations between C-IMT and serum osteocalcin level in premenopausal women after adjustment of age, but this association was eliminated after adjustment for other confounding factors.

Conclusions

Serum osteocalcin level was not independently associated with C-IMT in a metabolically healthy Chinese population.

【 授权许可】

   
2015 Luo et al.

【 图 表 】

Fig. 1.

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