Impact of serum omentin-1 levels on cardiac prognosis in patients with heart failure

Cardiovascular Diabetology

Isao Kubota¹  Takuya Miyamoto¹  Tetsuro Shishido¹  Takanori Arimoto¹  Hiroki Takahashi¹  Satoshi Nishiyama¹  Yoichiro Otaki¹  Yuki Honda¹  Miyuki Yokoyama¹  Daisuke Kinoshita¹  Shinpei Kadowaki¹  Tetsu Watanabe¹  Taro Narumi¹ 

[1] Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan

关键词: Prognosis;    Heart failure;    Omentin-1;   

Others  :  793059
DOI  :  10.1186/1475-2840-13-84

 received in 2014-03-04, accepted in 2014-04-15,  发布年份 2014

【 摘 要 】

Background

Various adipokines are reported to be associated with the development of heart failure (HF) through insulin resistance and chronic inflammation. Omentin-1 is a novel adipokine and is associated with incident coronary artery disease. However, it remains unclear whether serum omentin-1 levels are associated with cardiac prognosis in patients with HF.

Methods

We measured serum omentin-1 levels at admission in 136 consecutive patients with HF, and 20 control subjects without signs of significant heart disease. We prospectively followed patients with HF to endpoints of cardiac death or re-hospitalization for worsening HF.

Results

Serum omentin-1 levels were markedly lower in HF patients with cardiac events compared with to without. The patients who were in New York Heart Association (NYHA) functional class IV showed significantly lower serum omentin-1 levels compared to those in class II and III, whereas serum omentin-1 levels did not correlate with serum brain natriuretic peptide levels (r = 0.217, P = 0.011). We divided the HF patients into three groups based on the tertiles of serum omentin-1 level (low T1, middle T2, and high T3). Multivariate Cox hazard analysis showed that the lowest serum omentin-1 level (T1) was independently associated with cardiac events after adjustment for confounding factors (hazard ratio 5.78, 95% confidence interval 1.20-12.79). We divided the HF patients into two groups according to the median serum omentin-1 levels. Kaplan-Meier analysis revealed that the patients with low serum omentin-1 levels had a higher risk of cardiac events compared with those with high serum omentin-1 levels (log-rank test p < 0.001).

Conclusion

Decreased serum omentin-1 levels were associated with a poor cardiac outcome in patients with HF.

【 授权许可】

   
2014 Narumi et al.; licensee BioMed Central Ltd.

【 图 表 】

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