Effect of scheduled monitoring of liver function during anti-Tuberculosis treatment in a retrospective cohort in China

BMC Public Health

Siyan Zhan¹  Daiyu Hu²  Feiying Liu⁶  Yanli Yuan⁸  Xiaomeng Wang⁷  Shiming Cheng⁵  Peiyuan Deng⁴  Dehua Tu³  Zhirong Yang¹  Shaowen Tang¹  Yuan Zhang¹  Xiaozhen Lv¹  Yinyin Xia⁵  Shanshan Wu¹ 

[1] Department of Epidemiology and Bio-statistics, School of Public Health, Peking University Health Science Centre, 38 Xueyuan Road Haidian District, Beijing, 100191, China;Center for Disease Control and Prevention in Chongqing Municipality, Chongqing, China;Beijing Institute for Tuberculosis Control, Beijing, China;Center for Drug Reassessment, State Food and Drug Administration, Beijing, China;Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China;Center for Disease Control and Prevention in Guangxi Zhuang Autonomous Region, Nanning, China;Center for Disease Control and Prevention in Zhejiang Province, Hangzhou, China;Center for Disease Control and Prevention in Jilin Province, Changchun, China

关键词: Monitoring;    Hepatotoxicity;    Tuberculosis;   

Others  :  1163521
DOI  :  10.1186/1471-2458-12-454

 received in 2012-02-07, accepted in 2012-06-19,  发布年份 2012

【 摘 要 】

Background

Data on effect of regular liver function monitoring during anti-TB treatment is limited in China. This study aimed to evaluate the effects of scheduled liver function monitoring on identification of asymptomatic liver damage and anti-TB treatment outcomes during anti-TB treatment.

Methods

A retrospective analysis was performed based on a national-level cohort study. A total of 273 patients developing liver dysfunction were divided into two groups, 111 patients who were diagnosed through scheduled liver function test within two months after initiation of anti-TB treatment formed scheduled monitoring group, others who were diagnosed due to developing symptoms formed passive detection group (n = 162). The two groups were compared through clinical features, prognosis of liver dysfunction and impact on anti-TB treatment using propensity score weighting analysis.

Results

33.3% of 273 patients did not have any clinical symptoms, including 8 with severe hepatotoxicity. 1.8% in scheduled monitoring group and 11.1% in passive detection group required hospitalization (P = 0.004). Regarding the prognosis of liver dysfunction, most patients recovered, no death happened in scheduled monitoring group while 3 died in passive detection group. In terms of impact on anti-TB treatment, 35.1% in scheduled monitoring group and 56.8% in passive detection group changed their anti-TB treatment (P = 0.001).

Conclusions

Scheduled monitoring is effective in identifying asymptomatic liver damage, reducing hospitalization rate and improving compliance of anti-TB treatment.

【 授权许可】

   
2012 Wu et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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