Associations between alcohol use disorders and adherence to antiretroviral treatment and quality of life amongst people living with HIV/AIDS

BMC Public Health

Rachel Marie Maher³  Quyen Le Nguyen⁴  Cuong Duy Do²  Long Thanh Nguyen¹  Bach Xuan Tran³ 

[1] Authority of HIV/AIDS Control, Ministry of Health, Hanoi, Vietnam;Department of Infectious Diseases, Bach Mai Hospital, Hanoi, Vietnam;Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Vietnam;School of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam

关键词: Vietnam;    Adherence;    WHOQOL-HIV;    Antiretroviral treatment;    HIV/AIDS;    Alcohol use disorders;   

Others  :  1161356
DOI  :  10.1186/1471-2458-14-27

 received in 2013-03-07, accepted in 2014-01-05,  发布年份 2014

【 摘 要 】

Background

We examined the association of alcohol use disorders (AUD) with adherence to and health-related quality of life (HRQOL) outcomes of antiretroviral treatment (ART) for HIV/AIDS patients.

Methods

A cross-sectional multi-site survey was conducted in 468 drug users and 648 non-drug users (age: 35.4 ± 7.0 years; 63.8% male) in 3 epicentres of Vietnam. AUD, ART adherence, and HRQOL were measured using the Alcohol Use Disorders Identification Test - Consumption (AUDIT-C), the self-reported Visual Analogue Scale (VAS), and the World Health Organization Quality of Life instrument (WHOQOL-HIV BREF).

Results

35.0% of drug users were hazardous drinkers, compared to 25.9% of non-drug users. 22.3% of drug users engaged in binge drinking, and 25.9% reported suboptimal ART adherence. Adjusting for propensity scores of AUD, patients who had either at-risk or binge drinking behaviour were about twice as likely to be treatment non-adherent as those who did not have AUD. Hazardous drinkers reported small to medium decrements in the Performance, Physical, Social, Spirituality, and Environment quality of life domains. Binge drinkers had a slightly higher score in Social dimension.

Conclusion

AUD is prevalent and negatively affecting adherence to and HRQOL outcomes of ART services in injection-driven HIV epidemics. Screening and intervention are recommended for AUD, especially during the stable periods of ART. Other social and psychological interventions might also enhance patients’ responses to and outcomes of ART in Vietnam.

【 授权许可】

   
2014 Tran et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Schneider M, Chersich M, Neuman M, Parry C: Alcohol consumption and HIV/AIDS: the neglected interface. Addiction 2012, 107(8):1369-1371.
• [2]Mimiaga MJ, Thomas B, Mayer KH, Reisner SL, Menon S, Swaminathan S, Periyasamy M, Johnson CV, Safren SA: Alcohol use and HIV sexual risk among MSM in Chennai, India. Int J STD AIDS 2011, 22(3):121-125.
• [3]Schensul JJ, Singh SK, Gupta K, Bryant K, Verma R: Alcohol and HIV in India: a review of current research and intervention. AIDS Behav 2010, 14(Suppl 1):S1-7.
• [4]The Commission on AIDS in Asia: Redefining AIDS in Asia: crafting an effective response. Oxford University Press; 2008:258. Available at http://data.unaids.org/pub/report/2008/20080326_report_commission_aids_en.pdf webcite. Accessed November 1, 2012
• [5]Neuman MG, Monteiro M, Rehm J: Drug interactions between psychoactive substances and antiretroviral therapy in individuals infected with human immunodeficiency and hepatitis viruses. Subst Use Misuse 2006, 41(10–12):1395-1463.
• [6]Ferrari LF, Levine JD: Alcohol consumption enhances antiretroviral painful peripheral neuropathy by mitochondrial mechanisms. Eur J Neurosci 2010, 32(5):811-818.
• [7]Cheng DM, Libman H, Bridden C, Saitz R, Samet JH: Alcohol consumption and lipodystrophy in HIV-infected adults with alcohol problems. Alcohol 2009, 43(1):65-71.
• [8]Ghebremichael M, Paintsil E, Ickovics JR, Vlahov D, Schuman P, Boland R, Schoenbaum E, Moore J, Zhang H: Longitudinal association of alcohol use with HIV disease progression and psychological health of women with HIV. AIDS Care 2009, 21(7):834-841.
• [9]Tran BX, Ohinmaa A, Duong AT, Nguyen LT, Vu PX, Mills S, Houston S, Jacobs P: Cost-effectiveness of integrating methadone maintenance and antiretroviral treatment for HIV-positive drug users in Vietnam’s injection-driven HIV epidemics. Drug Alcohol Depend 2012, 125(3):260-266.
• [10]Tran BX, Ohinmaa A, Duong AT, Do NT, Nguyen LT, Mills S, Houston S, Jacobs P: Cost-effectiveness of methadone maintenance treatment for HIV-positive drug users in Vietnam. AIDS Care 2012, 24(3):283-290.
• [11]Tran BX, Nguyen N, Ohinmaa A, Duong AT, Nguyen LT, Van Hoang M, Vu PX, Veugelers PJ: Prevalence and correlates of alcohol use disorders during antiretroviral treatment in injection-driven HIV epidemics in Vietnam. Drug Alcohol Depend 2013, 127(1-3):39-44.
• [12]Ezard N, Oppenheimer E, Burton A, Schilperoord M, Macdonald D, Adelekan M, Sakarati A, van Ommeren M: Six rapid assessments of alcohol and other substance use in populations displaced by conflict. Confl Health 2011, 5(1):1. BioMed Central Full Text
• [13]Neramitpitagkul P, Lertpitakpong C, Yothasamut J, Thavorncharoensap M, Chaikledkaew U, Teerawattananon Y: Economic impact on health-care costs related to major diseases including HIV/AIDS due to alcohol drinking among Thai populations. Value Health 2009, 12(Suppl 3):S97-S100.
• [14]le Tho H, Singhasivanon P, Kaewkungwal J, Kaljee LM, Charoenkul C: Sexual behaviors of alcohol drinkers and non-drinkers among adolescents and young adults in Nha Trang, Vietnam. Southeast Asian J Trop Med Public Health 2007, 38(1):152-160.
• [15]Luo XF, Duan S, Duan QX, Pu YC, Yang YC, Wong FY, He N: Prevalence and correlates of alcohol use and subsequent sexual activity among adult males in a rural community of ethnic minorities in Yunnan Province, China. Biosci Trends 2012, 6(6):288-295.
• [16]Li Q, Li X, Stanton B: Alcohol use and sexual risk behaviors and outcomes in China: a literature review. AIDS Behav 2010, 14(6):1227-1236.
• [17]Tran BX, Ohinmaa A, Duong AT, Nguyen LT, Vu PX, Mills S, Houston S, Jacobs P: The cost-effectiveness and budget impact of Vietnam’s methadone maintenance treatment programme in HIV prevention and treatment among injection drug users. Glob Public Health 2012, 7(10):1080-1094.
• [18]Tran DA, Shakeshaft A, Ngo AD, Mallitt KA, Wilson D, Doran C, Zhang L: Determinants of antiretroviral therapy initiation and treatment outcomes for people living with HIV in Vietnam. HIV Clin Trials 2013, 14(1):21-33.
• [19]Tran BX, Nguyen LT, Nguyen NH, Hoang QV, Hwang J: Determinants of antiretroviral treatment adherence among HIV/AIDS patients: a multisite study. Glob Health Action 2013, 6:19570.
• [20]DA C d, Thorson A, Sonnerborg Hoa NP, Chuc NT, Phuc HD, Larsson M: Survival and causes of death among HIV-infected patients starting antiretroviral therapy in north-eastern Vietnam. Scand J Infect Dis 2012, 44(3):201-208.
• [21]Tran BX, Ohinmaa A, Duong AT, Do NT, Nguyen LT, Nguyen QC, Mills S, Jacobs P, Houston S: Changes in drug use are associated with health-related quality of life improvements among methadone maintenance patients with HIV/AIDS. Qual Life Res 2012, 21(4):613-623.
• [22]Van Tam V, Larsson M, Pharris A, Diedrichs B, Nguyen HP, Nguyen CT, Ho PD, Marrone G, Thorson A: Peer support and improved quality of life among persons living with HIV on antiretroviral treatment: a randomised controlled trial from north-eastern Vietnam. Health Qual Life Outcomes 2012, 10:53. BioMed Central Full Text
• [23]Tran BX, Ohinmaa A, Nguyen LT, Nguyen TA, Nguyen TH: Determinants of health-related quality of life in adults living with HIV in Vietnam. AIDS Care 2011, 23(10):1236-1245.
• [24]Tran BX, Ohinmaa A, Nguyen LT: Quality of life profile and psychometric properties of the EQ-5D-5 L in HIV/AIDS patients. Health Qual Life Outcomes 2012, 10(1):132. BioMed Central Full Text
• [25]Tran BX, Nguyen NPT: Patient Satisfaction with HIV/AIDS Care and Treatment in the Decentralization of Services Delivery in Vietnam. PLoS One 2012, 7(10):e46680.
• [26]Giang KB, Allebeck P, Spak F, Van Minh H, Dzung TV: Alcohol use and alcohol consumption-related problems in rural Vietnam: an epidemiological survey using AUDIT. Subst Use Misuse 2008, 43(3–4):481-495.
• [27]Broyles LM, Gordon AJ, Sereika SM, Ryan CM, Erlen JA: Predictive Utility of Brief Alcohol Use Disorders Identification Test (AUDIT) for human immunodeficiency virus antiretroviral medication nonadherence. Subst Abus 2011, 32(4):252-261.
• [28]Giordano TP, Guzman D, Clark R, Charlebois ED, Bangsberg DR: Measuring adherence to antiretroviral therapy in a diverse population using a visual analogue scale. HIV Clin Trials 2004, 5(2):74-79.
• [29]WHOQOL HIV Group: WHOQOL-HIV for quality of life assessment among people living with HIV and AIDS: results from the field test. AIDS Care 2004, 16(7):882-889.
• [30]O’Connell K, Skevington S, Saxena S: Preliminary development of the World Health Organsiation’s Quality of Life HIV instrument (WHOQOL-HIV): analysis of the pilot version. Soc Sci Med 2003, 57(7):1259-1275.
• [31]Tran BX, Ohinmaa A, Nguyen LT, Oosterhoff P, Vu PX, Vu TV, Larsson M: Gender differences in quality of life outcomes of HIV/AIDS treatment in the latent feminization of HIV epidemics in Vietnam. AIDS Care 2012, 24(10):1187-1196.
• [32]Tran BX: Quality of life outcomes of antiretroviral treatment for HIV/AIDS patients in Vietnam. PLoS One 2012, 7(7):e41062.
• [33]Linden A, Adams JL: Evaluating health management programmes over time: application of propensity score-based weighting to longitudinal data. J Eval Clin Pract 2010, 16(1):180-185.
• [34]Lu B: Propensity score matching with time-dependent covariates. Biometrics 2005, 61(3):721-728.
• [35]Austin PC, Escobar M, Kopec JA: The use of the Tobit model for analyzing measures of health status. Qual Life Res 2000, 9(8):901-910.
• [36]Azar MM, Springer SA, Meyer JP, Altice FL: A systematic review of the impact of alcohol use disorders on HIV treatment outcomes, adherence to antiretroviral therapy and health care utilization. Drug Alcohol Depend 2010, 112(3):178-193.
• [37]Senbanjo R, Wolff K, Marshall J: Excessive alcohol consumption is associated with reduced quality of life among methadone patients. Addiction 2007, 102(2):257-263.
• [38]Tran BX, Ohinmaa A, Duong AT, Do NT, Nguyen LT, Nguyen QC, Mills S, Jacobs P, Houston S: Changes in drug use are associated with health-related quality of life improvements among methadone maintenance patients with HIV/AIDS. Qual Life Res 2011, 21(4):613-623.
• [39]Tuunanen M, Aalto M, Seppa K: Binge drinking and its detection among middle-aged men using AUDIT, AUDIT-C and AUDIT-3. Drug Alcohol Rev 2007, 26(3):295-299.
• [40]Bradley KA, DeBenedetti AF, Volk RJ, Williams EC, Frank D, Kivlahan DR: AUDIT-C as a brief screen for alcohol misuse in primary care. Alcohol Clin Exp Res 2007, 31(7):1208-1217.
• [41]Frank D, DeBenedetti AF, Volk RJ, Williams EC, Kivlahan DR, Bradley KA: Effectiveness of the AUDIT-C as a screening test for alcohol misuse in three race/ethnic groups. J Gen Intern Med 2008, 23(6):781-787.
• [42]Mai Do Hoa MD, Pham Viet Cuong: ART adherence among people living with HIV/AIDS in Ha Noi and Hai Duong: situation and associated factors. J Pract Med, Hanoi 2010, 243&243(2011):5.