Quality of life profile and psychometric properties of the EQ-5D-5L in HIV/AIDS patients

Health and Quality of Life Outcomes

Research

Long Thanh Nguyen¹  Arto Ohinmaa²  Bach Xuan Tran³ 

[1] Authority of HIV/AIDS Control, Ministry of Health, Hanoi, Vietnam;School of Public Health, University of Alberta, Alberta, Canada;School of Public Health, University of Alberta, Alberta, Canada;Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Vietnam;

关键词: EQ-5D;    Quality of life;    Utility;    HIV;    Vietnam;    Psychometric properties;    Antiretroviral treatment;   

DOI  :  10.1186/1477-7525-10-132

 received in 2012-08-20, accepted in 2012-10-31,  发布年份 2012

来源: Springer

【 摘 要 】

ObjectivesWe assessed health-related quality of life (HRQOL), its associated factors, and examined measurement properties of the EuroQol - 5 Dimensions - 5 Levels (EQ-5D-5L) in HIV/AIDS patients.MethodsA cross-sectional multi-site survey was conducted in 1016 patients (age: 35.4 ± 7.0 years; 63.8% male) in three epicenters of Vietnam. Internal consistency reliability, convergent validity, and discriminative validity of the EQ-5D-5L and a visual analogue scale (VAS) were evaluated. Tobit censored regression models were used to identify predictors of HRQOL in HIV/AIDS patients.ResultsThe mean EQ-5D-5L single index and VAS were 0.65 (95% Confidence Interval (CI) = 0.63; 0.67) and 70.3 (95% CI = 69.2; 71.5). Cronbach’s alpha of five dimensions was 0.85. EQ-5D-5L has a good convergent validity with VAS (0.73). It discriminated patients at different HIV/AIDS stages, duration of ART, and CD4 cell count. Predictors of poorer HRQOL included being female, lower education level, unemployment, alcohol and drug use, CD4<200 cells/mL, and advanced HIV/AIDS stages.ConclusionThe EQ-5D-5L has good measurement properties in HIV/AIDS patients and holds potentials for monitoring ART outcomes. Integration of HRQOL measurement using EQ-5D-5L in HIV/AIDS clinical practice could be helpful for economic evaluation of HIV/AIDS interventions.

【 授权许可】

CC BY   
© Tran et al.; licensee BioMed Central Ltd. 2012