Health-related quality of life in chronic obstructive pulmonary disease patients in Korea

Health and Quality of Life Outcomes

Min-Woo Jo³  Yeon Mok Oh²  Seon-Ha Kim¹ 

[1] Department of Nursing, Dankook University, 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungnam 330-714, Korea;Department of Pulmonary and Critical Care Medicine, Asthma Center and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, 86, Asanbyeongwon-gil, Songpa-gu, Seoul 138-736, Korea;Department of Preventive Medicine, University of Ulsan College of Medicine, 86, Asanbyeongwon-gil, Songpa-gu, Seoul 138-736, Korea

关键词: CCQ;    EQ-5D;    Utility;    Quality of life;    Chronic obstructive pulmonary disease;   

Others  :  814932
DOI  :  10.1186/1477-7525-12-57

 received in 2013-10-21, accepted in 2014-04-21,  发布年份 2014

【 摘 要 】

Background

There are few publications on quality measurement of COPD health state according to the severity level using EQ-5D in Korea. The present study aimed to evaluate the health-related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD) in terms of disease severity in Korea.

Methods

Totally two hundred patients with COPD were consecutively recruited in one tertiary hospital of Korea. Each respondent was asked to fill out the questionnaire through a face-to-face interview after providing informed consent. The questionnaire included general and clinical characteristics as well as the EQ-5D and Clinical COPD Questionnaire (CCQ). HRQoL was evaluated according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria and severity of breathlessness.

Results

The adjusted mean EQ-5D index scores were 0.83, 0.88, 0.81 and 0.60 in stage I, II, III and IV, respectively. The EQ-5D index tended to decrease with GOLD criteria. The adjusted mean EQ-Visual Analog Scale (VAS) scores ranged from 65.1 in stage IV to 73.9 in stage I. The CCQ total scores deteriorated with an increasing GOLD stage and severity of breathlessness (all P < 0.001). The correlation between CCQ total score and EQ-5D index was −0.69.

Conclusions

Our study shows that HRQoL in COPD measured by EQ-5D and CCQ worsens with the GOLD stage and severity of breathlessness. EQ-5D and CCQ could be useful instruments for an evaluation of HRQoL in COPD patients in Korea.

【 授权许可】

   
2014 Kim et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]The National Lung Health Education Program Executive Committee: Strategies in preserving lung health and preventing COPD and associated diseases. The National Lung Health Education Program (NLHEP). Chest 1998, 113:123S-163S.
• [2]Ray D, Abel R, Selvaraj KG: A 5-yr prospective epidemiological study of chronic obstructive pulmonary disease in rural south India. Indian J Med Res 1995, 101:238-244.
• [3]Menezes AM, Perez-Padilla R, Jardim JR, Muino A, Lopez MV, Valdivia G, Montes de Oca M, Talamo C, Hallal PC, Victora CG: Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study. Lancet 2005, 366:1875-1881.
• [4]Ministry of Health and Welfare: Korean centers for disease control and prevention: 2010 Korea National Health and Nutrition Examination Survey (KNHANES V-1). Seoul: Ministry of Health and Welfare; 2011.
• [5]Pickard AS, Wilke C, Jung E, Patel S, Stavem K, Lee TA: Use of a preference-based measure of health (EQ-5D) in COPD and asthma. Respir Med 2008, 102:519-536.
• [6]EuroQol group: EuroQol--a new facility for the measurement of health-related quality of life. the EuroQol Group. Health Policy 1990, 16:199-208.
• [7]Rasanen P, Roine E, Sintonen H, Semberg-Konttinen V, Ryynanen OP, Roine R: Use of quality-adjusted life years for the estimation of effectiveness of health care: a systematic literature review. Int J Technol Assess Health Care 2006, 22:235-241.
• [8]van der Molen T, Willemse BW, Schokker S, ten Hacken NH, Postma DS, Juniper EF: Development, validity and responsiveness of the clinical COPD questionnaire. Health Qual Life Outcomes 2003, 1:13. BioMed Central Full Text
• [9]Damato S, Bonatti C, Frigo V, Pappagallo S, Raccanelli R, Rampoldi C, Rodi F: Validation of the Clinical COPD questionnaire in Italian language. Health Qual Life Outcomes 2005, 3:9. BioMed Central Full Text
• [10]EQ-5D User Guide: Basic Information On How To Use EQ-5D http://www.euroqol.org/fileadmin/user_upload/Documenten/PDF/User_Guide_v2_March_2009.pdf webcite
• [11]Lee YK, Nam HS, Chuang LH, Kim KY, Yang HK, Kwon IS, Kind P, Kweon SS, Kim YT: South Korean time trade-off values for EQ-5D health states: modeling with observed values for 101 health states. Value Health 2009, 12:1187-1193.
• [12]Global Initiative for Chronic Obstructive Lung Disease Inc: Global Strategy for The Diagnosis, Management, And Prevention Of Chronic Obstructive Pulmonary Disease. 2013. http://www.goldcopd.org/uploads/users/files/GOLD_Report_2013_Feb20.pdf webcite
• [13]Rutten-van Molken MP, Hoogendoorn M, Lamers LM: Holistic preferences for 1-year health profiles describing fluctuations in health: the case of chronic obstructive pulmonary disease. Pharmacoeconomics 2009, 27:465-477.
• [14]Kazis LE, Anderson JJ, Meenan RF: Effect sizes for interpreting changes in health status. Med Care 1989, 27:S178-189.
• [15]Cohen J: Statistical Power Analysis for The Behavioral Sciences: The T-Test For Means. 2nd edition. Hillsdale, New Jersy: Lawrence Erlbaum; 1988.
• [16]Kocks JW, Tuinenga MG, Uil SM, van den Berg JW, Stahl E, van der Molen T: Health status measurement in COPD: the minimal clinically important difference of the clinical COPD questionnaire. Respir Res 2006, 7:62. BioMed Central Full Text
• [17]Rutten-van Molken MP, Oostenbrink JB, Tashkin DP, Burkhart D, Monz BU: Does quality of life of COPD patients as measured by the generic EuroQol five-dimension questionnaire differentiate between COPD severity stages? Chest 2006, 130:1117-1128.
• [18]Stahl E, Lindberg A, Jansson SA, Ronmark E, Svensson K, Andersson F, Lofdahl CG, Lundback B: Health-related quality of life is related to COPD disease severity. Health Qual Life Outcomes 2005, 3:56. BioMed Central Full Text
• [19]Jo MW, Yun SC, Lee SI: Estimating quality weights for EQ-5D health states with the time trade-off method in South Korea. Value Health 2008, 11:1186-1189.
• [20]Westwood M, Bourbeau J, Jones PW, Cerulli A, Capkun-Niggli G, Worthy G: Relationship between FEV1 change and patient-reported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic review. Respir Res 2011, 12:40. BioMed Central Full Text
• [21]Pickard AS, Yang Y, Lee TA: Comparison of health-related quality of life measures in chronic obstructive pulmonary disease. Health Qual Life Outcomes 2011, 9:26. BioMed Central Full Text
• [22]Jones PW: Health status and the spiral of decline. COPD 2009, 6:59-63.
• [23]Yoo KH, Kim YS, Sheen SS, Park JH, Hwang YI, Kim SH, Yoon HI, Lim SC, Park JY, Park SJ, Seo KH, Kim KU, Oh YM, Lee NY, Kim JS, Oh KW, Kim YT, Park IW, Lee SD, Kim SK, Kim YK, Han SK: Prevalence of chronic obstructive pulmonary disease in Korea: the fourth Korean National Health and Nutrition Examination Survey, 2008. Respirology 2011, 16:659-665.