期刊论文详细信息
BMC Pulmonary Medicine
Short-term effects of a nicotine-free e-cigarette compared to a traditional cigarette in smokers and non-smokers
Stefano Nava3  Nadia Corcione4  Lara Pisani4  Antonella Balestrino2  Piero Ceriana2  Antonio Maria Morselli Labate1  Elena Nardi1  Alessandro Zanasi3  Marco Ferrari4 
[1] Laboratory of Biostatistics, Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy;Respiratory Unit, Fondazione S.Maugeri, IRCCS, Istituto Scientifico di Pavia, Pavia, Italy;Respiratory and Critical Care Unit, Sant’Orsola Malpighi Hospital, Via Massarenti 9, Bologna, 40138, Italy;Department of Specialistic, Diagnostic and Experimental Medicine, Respiratory and Critical Care Unit, Alma Mater Studiorum, Sant’Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
关键词: Concentration of carbon monoxide in exhaled breath;    Smoking;    Pulmonary function tests;    Electronic cigarettes;   
Others  :  1228322
DOI  :  10.1186/s12890-015-0106-z
 received in 2015-01-19, accepted in 2015-09-21,  发布年份 2015
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【 摘 要 】

Background

A few studies have assessed the short-term effects of low-dose nicotine e-cigarettes, while data about nicotine-free e-cigarettes (NF e-cigarettes) are scanty. Concerns have been expressed about the use of NF e-cigarettes, because of the high concentrations of propylene glycol and other compounds in the e-cigarette vapor.

Methods

This laboratory-based study was aimed to compare the effects of ad libitum use of a NF e-cigarette or and a traditional cigarette for 5 min in healthy adult smokers (n = 10) and non-smokers (n = 10).

The main outcome measures were pulmonary function tests, fraction of exhaled nitric oxide (FeNO) and fractional concentration of carbon monoxide (FeCO) in exhaled breath.

Results

The traditional cigarette induced statistically significant increases in FeCO in both smokers and non-smokers, while no significant changes were observed in FeNO. In non-smokers, the traditional cigarette induced a significant decrease from baseline in FEF75 (81 % ± 35 % vs 70.2 % ± 28.2 %, P = 0.013), while in smokers significant decreases were observed in FEF25 (101.3 % ± 16.4 % vs 93.5 % ± 31.7 %, P = 0.037), FEV 1(102.2 % ± 9.5 % vs 98.3 % ± 10 %, P = 0.037) and PEF (109.5 % ± 14.6 % vs 99.2 % ± 17.5 %, P = 0.009). In contrast, the only statistically significant effects induced by the NF e-cigarette in smokers were reductions in FEV 1(102.2 % ± 9.5 % vs 99.5 ± 7.6 %, P = 0.041) and FEF25 (103.4 % ± 16.4 % vs 94.2 % ± 16.2 %, P = 0.014).

Discussion

The present study demonstrated that the specific brand of NF e-cigarette utilized did not induce any majoracute effects. In contrast, several studies have shown that both traditional cigarettes and nicotine-containing e-cigarettes have acute effects on lung function. Our study expands on previous observations on the effects of NF e-cigarettes, but also for the first time describes the changes induced by smoking one traditional cigarette in a group of never smokers.

Conclusions

The short-term use of the specific brand of NF e-cigarette assessed in this study had no immediate adverse effects on non-smokers and only small effects on FEV 1and FEF25 in smokers. The long-term health effects of NF e-cigarette use are unknown but worthy of further investigations.

Trial registration

Clinicaltrials.gov: NCT02102191

【 授权许可】

   
2015 Ferrari et al.

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