Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson’s disease

BMC Complementary and Alternative Medicine

Sabina Lim⁵  Sung-Hoon Kim⁵  Bruce Rosen³  Geon-Ho Jahng⁴  Peggy Bosch²  Maurits van den Noort¹  Il-Hwan Choe⁵  Sujung Yeo⁵ 

[1] Free University of Brussels, Brussels, Belgium;Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands;Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, USA;College of Medicine, Kyung Hee University, Seoul, Republic of Korea;College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea

关键词: Patient;    Healthy;    Parkinson’s;    Functional magnetic resonance imaging;   

Others  :  1086724
DOI  :  10.1186/1472-6882-14-336

 received in 2013-09-12, accepted in 2014-06-23,  发布年份 2014

【 摘 要 】

Background

Acupuncture is increasingly used as an additional treatment for patients with Parkinson’s disease (PD).

Methods

In this functional magnetic resonance imaging study, brain activation in response to acupuncture in a group of 12 patients with PD was compared with a group of 12 healthy participants. Acupuncture was conducted on a specific acupoint, the right GB 34 (Yanglingquan), which is a frequently used acupoint for motor function treatment in the oriental medical field.

Results

Acupuncture stimulation on this acupoint activates the prefrontal cortex, precentral gyrus, and putamen in patients with PD; areas that are known to be impaired in patients with PD. Compared with healthy participants, patients with PD showed significantly higher brain activity in the prefrontal cortex and precentral gyrus, especially visible in the left hemisphere.

Conclusions

The neuroimaging results of our study suggest that in future acupuncture research; the prefrontal cortex as well as the precentral gyrus should be treated for symptoms of Parkinson’s disease and that GB 34 seems to be a suitable acupoint. Moreover, acupuncture evoked different brain activations in patients with Parkinson’s disease than in healthy participants in our study, stressing the importance of conducting acupuncture studies on both healthy participants as well as patients within the same study, in order to detect acupuncture efficacy.

Trial registration

KCT0001122 at cris.nih.go.kr (registration date: 20140530)

【 授权许可】

   
2014 Yeo et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

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