A new method of building permanent A-V block model: ablating his-bundle potential through femoral artery with pre-implanted biventricular pacemaker

BMC Cardiovascular Disorders

Lin Jia-Feng²  Li Yue-chun²  Wang Lu-ping²  Ye Wan-chun³  Li Jin²  Ye Hai-ge¹  Zheng Cheng² 

[1] Department of Hematology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China;Department of Cardiology, Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Road, Wenzhou, Zhejiang, China;Department of TCM, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

关键词: Disease models;    Beagle;    Radiofrequency ablation;    Biventricular pacemaker;    His-bundle potential;    A-V block;   

Others  :  1088685
DOI  :  10.1186/1471-2261-14-164

 received in 2014-06-06, accepted in 2014-11-14,  发布年份 2014

【 摘 要 】

Background

To explore the feasibility of a new method of achieving a permanent A-V block animal model.

Methods

16 beagles were randomly divided into two groups based on the method of their pre-implanted biventricular pacemakers. (1) In the first group (8 beagles), the A-V block model was achieved by ablating his-bundle potential at the site of the left ventricular superior-septum, under the aortic sinus, through femoral artery. (2) In the second group (8 beagles), the A-V block model was achieved by ablating his-bundle potential at the triangle of Koch, through femoral vein. A complete A-V block model was achieved as a standard in this study. The success rates, intraoperative arrhythmias, operative and X-ray exposure time, intraoperative bleeding amount were assessed in this two groups, both animal models were followed up for four weeks and then fasted to monitor myocardial pathological changes.

Results

The success rate of the first group, which with fewer intraoperative arrhythmias, and less operative and X-ray exposure time, was significantly higher than the second group.

Conclusions

Compared with traditional animal method, our new method of ablating his-bundle potential at the left ventricle from the femoral artery has a higher success rate, fewer occurrence of malignant arrhythmias, and less operation and X-ray time. Thus, our new method should be preferred in the building of Permanent A-V Block Model.

【 授权许可】

   
2014 Cheng et al.; licensee BioMed Central Ltd.

【 图 表 】

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