A new method of building permanent A-V block model: ablating his-bundle potential through femoral artery with pre-implanted biventricular pacemaker

BMC Cardiovascular Disorders

Research Article

Zheng Cheng¹  Li Yue-chun¹  Wang Lu-ping¹  Li Jin¹  Lin Jia-Feng¹  Ye Hai-ge²  Ye Wan-chun³ 

[1] Department of Cardiology, Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Road, Wenzhou, Zhejiang, China;Department of Hematology, First Affiliated Hospital of Wenzhou Medical University, 325000, Wenzhou, China;Department of TCM, First Affiliated Hospital of Wenzhou Medical University, 325000, Wenzhou, China;

关键词: A-V block;    His-bundle potential;    Biventricular pacemaker;    Radiofrequency ablation;    Beagle;    Disease models;   

DOI  :  10.1186/1471-2261-14-164

 received in 2014-06-06, accepted in 2014-11-14,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundTo explore the feasibility of a new method of achieving a permanent A-V block animal model.Methods16 beagles were randomly divided into two groups based on the method of their pre-implanted biventricular pacemakers. (1) In the first group (8 beagles), the A-V block model was achieved by ablating his-bundle potential at the site of the left ventricular superior-septum, under the aortic sinus, through femoral artery. (2) In the second group (8 beagles), the A-V block model was achieved by ablating his-bundle potential at the triangle of Koch, through femoral vein. A complete A-V block model was achieved as a standard in this study. The success rates, intraoperative arrhythmias, operative and X-ray exposure time, intraoperative bleeding amount were assessed in this two groups, both animal models were followed up for four weeks and then fasted to monitor myocardial pathological changes.ResultsThe success rate of the first group, which with fewer intraoperative arrhythmias, and less operative and X-ray exposure time, was significantly higher than the second group.ConclusionsCompared with traditional animal method, our new method of ablating his-bundle potential at the left ventricle from the femoral artery has a higher success rate, fewer occurrence of malignant arrhythmias, and less operation and X-ray time. Thus, our new method should be preferred in the building of Permanent A-V Block Model.

【 授权许可】

Unknown   
© Cheng et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.