High prevalence of Staphylococcus aureus and methicillin-resistant S. aureus colonization among healthy children attending public daycare centers in informal settlements in a large urban center in Brazil

BMC Infectious Diseases

Claudete Aparecida Araújo Cardoso²  Licínio Esmeraldo Silva²  Sérgio Setúbal²  Lee W Riley¹  Mariel Asbury Marlow¹  Verônica Afonso de Araújo²  Robert E Snyder¹  Thami Valadares Correa²  Monique Oliveira de e Silva²  Maria de Fátima Nogueira de Freitas³  Fábio Aguiar-Alves³  Eneida Dias Vianna Braga² 

[1] Division of Epidemiology, 530E Li Ka Shing Center, University of California, School of Public Health, Berkeley, CA 94720, USA;Departamento Materno Infantil, Avenida Marques de Paraná, 303, 3° andar, School of Medicine, Programa de Pós-graduação em Ciências Médicas, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil;Laboratório Universitário Rodolpho Albino, Programa de Pós-graduação em Patologia, Fluminense Federal University, Rua: Mário Viana, 523, Santa Rosa - Niterói– RJ CEP, Niterói, Rio de Janeiro 24241-002, Brazil

关键词: Favelas;    Informal settlements;    Slum;    Risk factors;    Nasal colonization;    Staphylococcus aureus;    Methicillin-resistant;    Community-associated;   

Others  :  1125439
DOI  :  10.1186/1471-2334-14-538

 received in 2014-02-08, accepted in 2014-09-24,  发布年份 2014

【 摘 要 】

Background

In the past decade methicillin-resistant Staphylococcus aureus (MRSA) has become increasingly prevalent in community settings. Attending a daycare center (DCC) is a known risk factor for colonization with MRSA. Brazil operates free, public DCCs for low-income families, some of which are located in census tracts defined by the Brazilian Census Bureau as informal settlements (aglomerados subnormais, AGSN). Physical and demographic characteristics of AGSNs suggest that S. aureus colonization prevalence would be higher, but little is known about the prevalence of MRSA in these settings.

Methods

We conducted a cross-sectional study to assess risk factors for S. aureus and MRSA colonization among children attending DCCs located in AGSN vs non-AGSN. Nasal swabs were collected from children aged three months to six years in 23 public DCCs in Niterói, Brazil between August 2011 and October 2012.

Results

Of 500 children enrolled in the study, 240 (48%) were colonized with S. aureus and 31 (6.2%) were colonized with MRSA. Children attending DCCs in AGSNs were 2.32 times more likely to be colonized with S. aureus (95% CI: 1.32, 4.08), and 3.27 times more likely to be colonized with MRSA than children attending non-AGSN DCCs (95% CI: 1.52, 7.01), adjusted for confounding variables.

Conclusion

S. aureus and MRSA colonization prevalence among children attending DCCs in informal settlement census tracts was higher than previously reported in healthy pre-school children in Latin America. Our data suggest that transmission may occur more frequently in DCCs rather than at home, highlighting the importance of DCCs in AGSNs as potential MRSA reservoirs. This finding underscores the importance of local epidemiologic surveillance in vulnerable AGSN communities.

【 授权许可】

   
2014 Braga et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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