A pilot study to evaluate the feasibility of individualized yoga for inpatient children receiving intensive chemotherapy

BMC Complementary and Alternative Medicine

Lillian Sung¹  George Tomlinson²  Christine Armstrong¹  Janine Piscione¹  Deborah Tomlinson³  Tanya Hesser³  Cathy O’Sullivan³  Michelle Lee³  Tal Schechter¹  Caroline Diorio³ 

[1]Division of Haematology/Oncology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada

[2]Toronto General Hospital, 200 Elizabeth Street, Toronto, ON, Canada

[3]Child Health Evaluative Sciences, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, 686 Bay St, Toronto, ON, Canada

关键词: Quality of life;    Fatigue;    Haematopoietic stem cell transplantation;    Chemotherapy;    Children;    Yoga;    Pilot;   

Others  :  1117835
DOI  :  10.1186/s12906-015-0529-3

 received in 2014-02-05, accepted in 2015-01-16,  发布年份 2015

【 摘 要 】

Background

Fatigue is an important problem in paediatric cancer patients and yoga may be an effective intervention. The primary objective was to determine the feasibility of individualized yoga for hospitalized children receiving intensive chemotherapy.

Methods

We included English-speaking children and adolescents aged 7–18 years receiving intensive chemotherapy or haematopoietic stem cell transplantation (HSCT). Yoga was conducted three times weekly for three weeks. The primary outcome was feasibility, defined as ability to deliver at least 60% of planned sessions. Secondary outcomes were parent-reported Pediatric Quality of Life Inventory (PedsQL) Multidimensional Fatigue Scale, Fatigue Scale-Parent, PedsQL Generic Core Scales and PedsQL Acute Cancer Module.

Results

Between January and October 2013, 11 patients were enrolled. Median age was 14.0 (range 7.7-16.4) years and 6 (55%) were boys. Yoga was feasible with 10/11 participants meeting the threshold for feasibility. The median number of yoga sessions was 9 (range 3–13). No adverse events were attributed to yoga. Mean ± standard deviation for the day 21 proxy-reported PedsQL general fatigue scores was 55.6 ± 15.5. Qualitative comments suggested design changes for future yoga studies.

Conclusions

Individualized yoga is feasible for inpatient children receiving intensive chemotherapy. Future work will include development and conduct of a randomized trial for fatigue amelioration.

Trial registration

ClinicalTrials.gov NCT02105389 webcite.

【 授权许可】

   
2015 Diorio et al.; licensee BioMed Central.

【 参考文献 】

• [1]Mortimer JE, Barsevick AM, Bennett CL, Berger AM, Cleeland C, Devader SR, et al.: Studying Cancer-Related Fatigue: Report of the NCCN Scientific Research Committee. J Natl Compr Canc Netw 2010, 8(12):1331-9.
• [2]Mitchell SA: Cancer-related fatigue: state of the science. PM R 2010, 2(5):364-83.
• [3]Erickson JM, Beck SL, Christian B, Dudley WN, Hollen PJ, Albritton K, et al.: Patterns of fatigue in adolescents receiving chemotherapy. Oncol Nurs Forum 2010, 37(4):444-55.
• [4]Baggott C, Dodd M, Kennedy C, Marina N, Matthay KK, Cooper BA, et al.: Changes in children's reports of symptom occurrence and severity during a course of myelosuppressive chemotherapy. J Pediatr Oncol Nurs 2010, 27(6):307-15.
• [5]Dupuis LL, Milne-Wren C, Cassidy M, Barrera M, Portwine C, Johnston DL, et al.: Symptom assessment in children receiving cancer therapy: the parents' perspective. Support Care Cancer 2010, 18(3):281-99.
• [6]Walker AJ, Gedaly-Duff V, Miaskowski C, Nail L: Differences in symptom occurrence, frequency, intensity, and distress in adolescents prior to and one week after the administration of chemotherapy. J Pediatr Oncol Nurs 2010, 27(5):259-65.
• [7]Collins JJ, Byrnes ME, Dunkel IJ, Lapin J, Nadel T, Thaler HT, et al.: The measurement of symptoms in children with cancer. J Pain Symptom Manage 2000, 19(5):363-77.
• [8]Gibson F, Garnett M, Richardson A, Edwards J, Sepion B: Heavy to carry: a survey of parents' and healthcare professionals' perceptions of cancer-related fatigue in children and young people. Cancer Nurs 2005, 28(1):27-35.
• [9]Collins JJ, Devine TD, Dick GS, Johnson EA, Kilham HA, Pinkerton CR, et al.: The measurement of symptoms in young children with cancer: the validation of the Memorial Symptom Assessment Scale in children aged 7–12. J Pain Symptom Manage 2002, 23(1):10-6.
• [10]Berger AM, Mooney K, Alvarez-Perez A, Breitbart WS, Carpenter KM, Cella D, et al. National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: Cancer-Related Fatigue (Version 1.2015). Retrieved from http://www.nccn.org/professionals/physician_gls/f_guidelines.asp#fatigue.
• [11]Tomlinson D, Diorio C, Beyene J, Sung L: The effect of exercise on cancer-related fatigue. A meta-analysis. Am J Phys Med Rehabil. in press.
• [12]Thabane L, Ma J, Chu R, Cheng J, Ismaila A, Rios LP, et al.: A tutorial on pilot studies: the what, why and how. BMC Med Res Methodol 2010, 10:1. BioMed Central Full Text
• [13]Tomlinson D, Hinds PS, Ethier MC, Ness KK, Zupanec S, Sung L: Psychometric Properties of Instruments Used to Measure Fatigue in Children and Adolescents With Cancer: A Systematic Review. J Pain Symptom Manage 2013, 45(1):83-91.
• [14]Varni JW, Burwinkle TM, Katz ER, Meeske K, Dickinson P: The PedsQL in pediatric cancer: reliability and validity of the Pediatric Quality of Life Inventory Generic Core Scales, Multidimensional Fatigue Scale, and Cancer Module. Cancer 2002, 94(7):2090-106.
• [15]Hinds PS, Yang J, Gattuso JS, Hockenberry M, Jones H, Zupanec S, et al.: Psychometric and clinical assessment of the 10-item reduced version of the Fatigue Scale-Child instrument. J Pain Symptom Manage 2010, 39(3):572-8.
• [16]Mandrell BN, Yang J, Hooke MC, Wang C, Gattuso JS, Hockenberry M, et al.: Psychometric and clinical assessment of the 13-item reduced version of the fatigue scale-adolescent instrument. J Pediatr Oncol Nurs 2011, 28(5):287-94.
• [17]Hinds PS, Hockenberry M, Tong X, Rai SN, Gattuso JS, McCarthy K, et al.: Validity and reliability of a new instrument to measure cancer-related fatigue in adolescents. J Pain Symptom Manage 2007, 34(6):607-18.
• [18]Varni JW, Katz ER, Seid M, Quiggins DJ, Friedman-Bender A: The pediatric cancer quality of life inventory-32 (PCQL-32): I. Reliability and validity. Cancer 1998, 82(6):1184-96.
• [19]Varni JW, Katz ER, Seid M, Quiggins DJ, Friedman-Bender A, Castro CM: The Pediatric Cancer Quality of Life Inventory (PCQL). I. Instrument development, descriptive statistics, and cross-informant variance. J Behav Med 1998, 21(2):179-204.
• [20]Varni JW, Rode CA, Seid M, Katz ER, Friedman-Bender A, Quiggins DJ: The Pediatric Cancer Quality of Life Inventory-32 (PCQL-32). II. Feasibility and range of measurement. J Behav Med 1999, 22(4):397-406.
• [21]Varni JW, Seid M, Kurtin PS: PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. Med Care 2001, 39(8):800-12.
• [22]Brazier JE, Harper R, Jones NM, O'Cathain A, Thomas KJ, Usherwood T, et al.: Validating the SF-36 health survey questionnaire: new outcome measure for primary care. BMJ 1992, 305(6846):160-4.
• [23]Jenkinson C, Wright L, Coulter A: Criterion validity and reliability of the SF-36 in a population sample. Qual Life Res 1994, 3(1):7-12.
• [24]Thygeson MV, Hooke MC, Clapsaddle J, Robbins A, Moquist K: Peaceful play yoga: serenity and balance for children with cancer and their parents. J Pediatr Oncol Nurs 2010, 27(5):276-84.
• [25]Geyer R, Lyons A, Amazeen L, Alishio L, Cooks L: Feasibility study: the effect of therapeutic yoga on quality of life in children hospitalized with cancer. Pediatr Phys Ther 2011, 23(4):375-9.
• [26]Wurz A, Chamorro-Vina C, Guilcher GM, Schulte F, Culos-Reed SN: The feasibility and benefits of a 12-week yoga intervention for pediatric cacner out-patients. Pediatr Blood Cancer 2014, 61(10):1828-34.