Study protocol: the Childhood to Adolescence Transition Study (CATS)

BMC Pediatrics

George C Patton³  Felice Jacka⁷  Melissa Wake³  Rosa Alati⁶  Louisa Degenhardt⁹  Susan M Sawyer³  Fiona Mensah²  Helena Romaniuk²  Craig Olsson⁷  Jo Williams³  Timothy Olds¹  Jordana K Bayer⁵  Russell M Viner⁸  Nicholas B Allen⁴  Julian G Simmons⁴  Lisa K Mundy^1,10 

[1] Health and Use of Time (HUT) Group, University of South Australia, Adelaide, Australia;Clinical Epidemiology and Biostatistics Unit, The Royal Children's Hospital, Melbourne, Australia;Department of Paediatrics, The University of Melbourne, Melbourne, Australia;Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Australia;La Trobe University, Melbourne, Australia;Centre for Youth Substance Abuse Research, University of Queensland, Brisbane, Australia;Deakin University, Melbourne, Australia;UCL Institute of Child Health, University College London, London, UK;Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia;Centre for Adolescent Health, The Royal Children’s Hospital, Melbourne, Australia

关键词: Epidemiology;    Protocol;    Public health;    Cohort studies;    Adolescent;    Gonadarche;    Adrenarche;    Hormones;    Puberty;   

Others  :  1144448
DOI  :  10.1186/1471-2431-13-160

 received in 2013-10-01, accepted in 2013-10-04,  发布年份 2013

【 摘 要 】

Background

Puberty is a multifaceted developmental process that begins in late-childhood with a cascade of endocrine changes that ultimately lead to sexual maturation and reproductive capability. The transition through puberty is marked by an increased risk for the onset of a range of health problems, particularly those related to the control of behaviour and emotion. Early onset puberty is associated with a greater risk of cancers of the reproductive tract and cardiovascular disease. Previous studies have had methodological limitations and have tended to view puberty as a unitary process, with little distinction between adrenarche, gonadarche and linear growth. The Childhood to Adolescence Transition Study (CATS) aims to prospectively examine associations between the timing and stage of the different hormonally-mediated changes, as well as the onset and course of common health and behavioural problems that emerge in the transition from childhood to adolescence. The initial focus of CATS is on adrenarche, the first hormonal process in the pubertal cascade, which begins for most children at around 8 years of age.

Methods/Design

CATS is a longitudinal population-based cohort study. All Grade 3 students (8–9 years of age) from a stratified cluster sample of schools in Melbourne, Australia were invited to take part. In total, 1239 students and a parent/guardian were recruited to participate in the study. Measures are repeated annually and comprise student, parent and teacher questionnaires, and student anthropometric measurements. A saliva sample was collected from students at baseline and will be repeated at later waves, with the primary purpose of measuring hormonal indices of adrenarche and gonadarche.

Discussion

CATS is uniquely placed to capture biological and phenotypic indices of the pubertal process from its earliest manifestations, together with anthropometric measures and assessment of child health and development. The cohort will provide rich detail of the development, lifestyle, external circumstances and health of children during the transition from childhood through to adolescence. Baseline associations between the hormonal measures and measures of mental health and behaviour will initially be examined cross-sectionally, and then in later waves longitudinally. CATS will make a unique contribution to the understanding of adrenarche and puberty in children’s health and development.

【 授权许可】

   
2013 Mundy et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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