Protective variant associated with alcohol dependence in a Mexican American cohort

BMC Medical Genetics

Cindy L Ehlers⁴  Nicholas J Schork²  Kirk C Wilhelmsen³  Ian R Gizer¹  Trina M Norden-Krichmar⁴ 

[1] Department of Psychological Sciences, University of Missouri, Columbia 65211, MO, USA;Department of Human Biology, J. Craig Venter Institute, La Jolla 92037, CA, USA;Department of Genetics and Neurology, University of North Carolina, Chapel Hill 27599, NC, USA;Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla 92037, CA, USA

关键词: Mexican Americans;    ADH;    Alcohol dehydrogenase;    Alcohol dependence;   

Others  :  1090000
DOI  :  10.1186/s12881-014-0136-z

 received in 2014-07-18, accepted in 2014-12-08,  发布年份 2014

【 摘 要 】

Background

Mexican Americans, particularly those born in the United States, are at greater risk for alcohol associated morbidity and mortality. The present study sought to investigate whether specific genetic variants may be associated with alcohol use disorder phenotypes in a select population of Mexican American young adults.

Methods

The study evaluated a cohort of 427 (age 18 – 30 years) Mexican American men (n = 171) and women (n = 256). Information on alcohol dependence was obtained through interview using the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). For all subjects, DNA was extracted from blood samples, followed by genotyping using an Affymetrix Axiom Exome1A chip.

Results

A protective variant (rs991316) located downstream from the ADH7 (alcohol dehydrogenase 7) gene showed suggestive significance in association with alcohol dependence symptom counts derived from DSM-III-R and DSM-IV criteria, as well as to clustered alcohol dependence symptoms. Additional linkage analysis suggested that nearby variants in linkage disequilibrium with rs991316 were not responsible for the observed association with the alcohol dependence phenotypes in this study.

Conclusions

ADH7 has been shown to have a protective role against alcohol dependence in previous studies involving other ethnicities, but has not been reported for Mexican Americans. These results suggest that variants near ADH7 may play a role in protection from alcohol dependence in this Mexican American cohort.

【 授权许可】

   
2014 Norden-Krichmar et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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