Factors associated with latent tuberculosis among asylum seekers in Switzerland: a cross-sectional study in Vaud County

BMC Infectious Diseases

Patrick Bodenmann³  Charlotte Deslarzes¹  Oscar Daher⁴  Mohamed Faouzi²  Jean-Pierre Zellweger⁵  Apostolos Sarivalasis³ 

[1] Nurse, Health Center (CSI), Rue du Bugnon 44, 1011, Lausanne, Vaud, Switzerland;Institute of Social and Preventive Medicine (IUMSP), Rue du Bugnon 44, 1011, Lausanne, Vaud, Switzerland;Department of Ambulatory Care and Community Medicine (PMU), Rue du Bugnon 44, 1011, Lausanne, Vaud, Switzerland;Health Center – Sainte-Croix Hospital (CSSC), Rue des Rosiers 29,1450 Ste-Croix, Vaud, Switzerland;Swiss Lung Association, Vaud section (LPVD), Av de Provence 4, 1007, Lausanne, Vaud, Switzerland

关键词: Interferon gamma release assay;    Predictive score;    Risk factors;    Tuberculosis;    Latent tuberculosis infection;    Asylum seeker;   

Others  :  1159606
DOI  :  10.1186/1471-2334-12-285

 received in 2012-05-12, accepted in 2012-10-29,  发布年份 2012

【 摘 要 】

Background

Screening and treatment of latent tuberculosis infection (LTBI) in asylum seekers (AS) may prevent future cases of tuberculosis. As the screening with Interferon Gamma Release Assay (IGRA) is costly, the objective of this study was to assess which factors were associated with LTBI and to define a score allowing the selection of AS with the highest risk of LTBI.

Methods

In across-sectional study, AS seekers recently arrived in Vaud County, after screening for tuberculosis at the border were offered screening for LTBI with T-SPOT.TB and questionnaire on potentially risk factors. The factors associated with LTBI were analyzed by univariate and multivariate regression.

Results

Among 393 adult AS, 98 (24.93%) had a positive IGRA response, five of them with active tuberculosis previously undetected. Six factors associated with LTBI were identified in multivariate analysis: origin, travel conditions, marital status, cough, age and prior TB exposure. Their combination leads to a robust LTBI predictive score.

Conclusions

The prevalence of LTBI and active tuberculosis in AS is high. A predictive score integrating six factors could identify the asylum seekers with the highest risk for LTBI.

【 授权许可】

   
2012 Sarivalasis et al.; licensee BioMed Central Ltd.

【 图 表 】

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